Primaquine for Plasmodium vivax radical cure: What we do not know and why it matters
| Autor: | Kieran Tebben, Benoit Witkowski, David Serre, Jean Popovici |
|---|---|
| Přispěvatelé: | Malaria Molecular Epidemiology, Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), University of Maryland School of Medicine, University of Maryland System, David Serre acknowledges the NIH for financial support (1R01AI146590). |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Primaquine 030231 tropical medicine Plasmodium vivax Infectious and parasitic diseases RC109-216 03 medical and health sciences Antimalarials 0302 clinical medicine parasitic diseases Malaria Vivax Medicine Animals Humans Pharmacology (medical) Parasites MESH: Animals MESH: Parasites Pharmacology MESH: Humans biology business.industry MESH: Malaria Vivax MESH: Primaquine biology.organism_classification Case management Special issue articles on 'Drug Resistance' MESH: Antimalarials 3. Good health MESH: Plasmodium vivax 030104 developmental biology Infectious Diseases [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology Liver Immunology Parasitology business medicine.drug MESH: Liver |
| Zdroj: | International Journal for Parasitology: Drugs and Drug Resistance, Vol 15, Iss, Pp 36-42 (2021) International journal for parasitology. Drugs and drug resistance International journal for parasitology. Drugs and drug resistance, Elsevier, 2021, 15, pp.36-42. ⟨10.1016/j.ijpddr.2020.12.004⟩ International Journal for Parasitology: Drugs and Drug Resistance |
| ISSN: | 2211-3207 |
| Popis: | Plasmodium vivax radical cure requires the administration of a blood schizonticide for killing blood-stage parasites and the addition of a drug able to kill hypnozoites, the dormant parasite stages residing in the liver of infected patients. All drugs used clinically for killing hypnozoites are 8-aminoquinolines and among them, primaquine has been at the forefront of P. vivax case management for decades. We discuss here the possible factors that could lead to the emergence and selection of P. vivax primaquine resistant parasites and emphasize on how a better understanding of the mechanisms underlying primaquine treatment and hypnozoite biology is needed to prevent this catastrophic scenario from happening. Graphical abstract Image 1 |
| Databáze: | OpenAIRE |
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