Synthesis of Novel Phosphorylated Guanidine Derivatives from Cyanamide and Their Anti-inflammatory Activity
| Autor: | Venkata Ramana Katla, Rasheed Syed, Hema Kumar Kuntrapakam, Chandra Sekhar Kuruva, Naga Raju Chamarthi |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Stereochemistry
medicine.drug_class Anti-Inflammatory Agents Thiophosphoryl chloride Substituent Carrageenan Anti-inflammatory chemistry.chemical_compound In vivo Drug Discovery medicine Animals Edema Humans Phosphorylation Rats Wistar Guanidine Foot Erythrocyte Membrane General Chemistry General Medicine In vitro Rats chemistry Benzothiazole Cyanamide |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 61:25-32 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | A series of novel guanidine derivatives were synthesized in three steps and their anti-inflammatory activities in vitro and in vivo evaluated. 2-Aminopyridin-3-ol (1) was reacted with thiophosphoryl chloride (2) to give a monochloride (3). It was further reacted with cyanamide to afford the corresponding cyanamine (4), which was subsequently reacted with different heterocyclic amines to form the title compounds (5a–l). The substituent in the guanidine function affected the potency of anti-inflammatory activity. The compounds having benzothiazole, fluorophenyl, and piperazinyl moieties enhanced the anti-inflammatory activity. =× =× |
| Databáze: | OpenAIRE |
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