Hippo signaling in the ovary and polycystic ovarian syndrome
| Autor: | Kevin Eggan, Alan S. Penzias, Paul M Sweetnam, Denny Sakkas, Kristi Maas, Sheyla Mirabal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
endocrine system endocrine system diseases Ovary Disease Fertilization in Vitro Protein Serine-Threonine Kinases Bioinformatics 03 medical and health sciences 0302 clinical medicine Genetics Medicine Tensin PTEN Humans Hippo Signaling Pathway Protein kinase B Genetics (clinical) Hippo signaling pathway 030219 obstetrics & reproductive medicine biology business.industry Obstetrics and Gynecology General Medicine Human genetics female genital diseases and pregnancy complications 030104 developmental biology medicine.anatomical_structure Reproductive Physiology and Disease Reproductive Medicine Hippo signaling biology.protein Oocytes Female business Infertility Female Developmental Biology Polycystic Ovary Syndrome Signal Transduction |
| Popis: | PURPOSE: To provide a commentary on our understanding of the role that the Hippo signaling pathway may play in patients with polycystic ovarian syndrome (PCOS) and how this understanding may impact the diagnosis of PCOS. METHODS: We assessed publications discussing the role of the Hippo signaling pathway in the ovary. In particular, we discuss how Hippo signaling disruption after ovarian fragmentation, combined with treating ovarian fragments with phosphatase and tensin homolog (PTEN) inhibitors and phosphoinositide-3-kinase stimulators to augment AKT signaling, has been used in treatment of patients with primary ovarian insufficiency. Furthermore, we discuss our own data on variations in Hippo signaling pathway gene expression in cumulus cells isolated from women undergoing IVF with a previous diagnosis of PCOS. RESULTS AND CONCLUSIONS: Aberrant Hippo signaling in PCOS patients is likely a contributing mechanism to the multifactorial etiology of the disease. Given the challenge of discerning the underlying etiology of oligo-ovulation in some patients, especially those with normal body mass indices, and the need for customized stimulation protocols for PCOS patients who have an increased risk of over-response and higher percentage of immature oocyte yield, it is important to identify these patients prior to treatment. Hippo gene expression fingerprints could potentially be used to more accurately define patients with PCOS. Additionally, targeting this pathway with pharmacologic agents could lead to non-surgical therapeutic options for PCOS. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10815-018-1235-0) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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