Long-Term Outcomes of Pediatric Meningioma Surgery: Single Center Experience with 23 Patients
| Autor: | Firat Narin, Ilkay Isikay, Sahin Hanalioglu, Burcak Bilginer, Ibrahim Basar |
|---|---|
| Přispěvatelé: | Beyin ve Sinir Cerrahisi |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Prognostic variable Adolescent Single Center Childhood Meningioma Surgery Cohort Studies 03 medical and health sciences 0302 clinical medicine Recurrence Meningeal Neoplasms medicine Humans Neurofibromatosis Child Survival rate Retrospective Studies Univariate analysis business.industry Glasgow Outcome Scale Retrospective cohort study Prognosis medicine.disease Surgery Survival Rate Treatment Outcome Child Preschool Female Neurology (clinical) Neoplasm Recurrence Local Meningioma business 030217 neurology & neurosurgery Cohort study |
| Popis: | Aim: To evaluate the long-term outcomes and prognostic variables in a surgical cohort of pediatric meningiomas treated in a single institution. Material and methods: Medical records and follow-up notes of 23 pediatric patients aged < 18 years (12 male and 11 female; mean age on presentation, 13.1 ± 4.4 years) harboring 27 meningiomas operated between 1994 and 01/2019 at Hacettepe University Ihsan Dogramaci Children’s Hospital were evaluated. Results: One patient had neurofibromatosis (NF) type 1, and five patients had NF2. Tumors were most commonly located in the convexity (n=6) and parasagittal or falcine (n=6). Gross total resection was performed in 70.4% of cases. WHO grade I tumors accounted for 56% of all cases, whereas high-grade meningiomas accounted for 44% (33% grade II, 11% grade III). The mean follow-up duration was 10.3 ± 7.7 years. Three patients (13%) died during follow-up, and 76.2% of the patients had favorable outcome (Glasgow Outcome Scale > 3) during the last follow-up assessment. Ten patients (43.5%) had relapse. In univariate analysis, low histological grade (p=0.030) and gross total resection (p=0.024) were associated with favorable outcome. The 10-year overall survival rate was 86%. Conclusion: Meningiomas in the pediatric age group are surgically treatable tumors with fairly good outcomes. However, relapses are common even for low-grade tumors; therefore, long-term surveillance and aggressive treatment are needed. |
| Databáze: | OpenAIRE |
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