Effects of pretreatment with verapamil on the toxicokinetics of soman in rabbits and distribution in mouse brain and diaphragm
| Autor: | Jian-zhong Qiao, Jin-Xiu Ruan, Zheng-Yan Song, Zhen-Qing Zhang, Wei-Dong Yu, Jin-Tong Li |
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| Rok vydání: | 2003 |
| Předmět: |
Chromatography
Gas Ratón Vasodilator Agents Diaphragm Soman Pharmacology Toxicology Mice chemistry.chemical_compound medicine Animals Distribution (pharmacology) Neurotoxin Toxicokinetics Lagomorpha biology Brain Stereoisomerism General Medicine Calcium Channel Blockers biology.organism_classification Diaphragm (structural system) Verapamil chemistry Area Under Curve Anesthesia Inactivation Metabolic Cholinesterase Inhibitors Rabbits Half-Life medicine.drug |
| Zdroj: | Toxicology Letters. 138:227-233 |
| ISSN: | 0378-4274 |
| Popis: | The effects of verapamil on the elimination of soman in rabbit blood and distribution in mouse brain and diaphragm by determining the concentration of P(-)soman using the chirasil capillary gas chromatographic analysis method were studied in order to study the effects of verapamil on the metabolic detoxification of soman. Verapamil (10 mg kg(-1), im, 30 min before soman administration) could significantly reduce the concentration of P(-)soman in rabbit blood at 15, 60, 90, 120, 180 and 240 s after soman injection (43.2 microg kg(-1), iv) as compared to soman-treated control animal respectively. Toxicokinetics parameters showed verapamil could increase clearance rate from 20.8+/-1.51 to 44.3+/-7.0 ml kg(-1)s(-1) and reduce AUC of P(-)soman from 2.08+/-0.151 to 0.996+/-0.172 mg s l(-1). For experiments in mice, verapamil could reduce the concentration P(-)soman in diaphragm from 74.7, 70.5, 88.7 to 41.1, 39.0, 49.3 ng g(-1) at the time of 30, 90, 120 s after intoxication of soman subcutaneously vs. soman control respectively, but it had no influence on the concentration of free P(-)soman in brain. Verapamil accelerated the elimination of P(-)soman in the rabbits blood and reduced the distribution of P(-)soman in the mouse diaphragm. |
| Databáze: | OpenAIRE |
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