Longitudinal predictors of bronchial hyperresponsiveness and FEV1 decline in bakers

Autor: Michel Grzebyk, N. Massin, M. Hery, Pascal Wild, Christophe Paris, Valérie Demange
Přispěvatelé: Institut national de recherche et de sécurité (Vandoeuvre lès Nancy) (INRS ( Vandoeuvre lès Nancy)), CHU Pontchaillou [Rennes], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), INRS, Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Chard-Hutchinson, Xavier
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Spirometry
medicine.medical_specialty
Longitudinal study
Bakers
Epidemiology
[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
[SDV.EE.SANT] Life Sciences [q-bio]/Ecology
environment/Health
030212 general & internal medicine
Respiratory health
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology
environment/Health
medicine.diagnostic_test
business.industry
Public Health
Environmental and Occupational Health
Occupational exposure
medicine.disease
030210 environmental & occupational health
Lung function
respiratory tract diseases
Bronchial hyperresponsiveness
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Mixed effects
[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
Methacholine
Bronchial challenge test
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
business
medicine.drug
Zdroj: International Archives of Occupational and Environmental Health
International Archives of Occupational and Environmental Health, Springer Verlag, 2021, 94 (4), pp.751-761. ⟨10.1007/s00420-020-01628-0⟩
International Archives of Occupational and Environmental Health, 2021, 94 (4), pp.751-761. ⟨10.1007/s00420-020-01628-0⟩
ISSN: 0340-0131
1432-1246
DOI: 10.1007/s00420-020-01628-0⟩
Popis: International audience; Objective To determine long-term predictors of bronchial hyperresponsiveness (BHR) and forced expiratory volume in one second (FEV1) decline.Methods A longitudinal study in 110 bakers in 4 industrial bakeries and 38 non-exposed workers was conducted at the workplace with a mean of 3.3 visits per subject over a period of 13 years and a mean duration of follow-up of 6 years in bakers and 8 years in non-exposed subjects. A respiratory health questionnaire was administered; occupational allergen skin prick tests, spirometry and a methacholine bronchial challenge test were performed at each visit. In each bakery, full-shift dust samples of the inhalable fraction were obtained in order to assess the exposure of each job assignment. The repeated measurements of BHR and FEV1 were analyzed using mixed effects logistic and linear regression models in subjects seen at least twice.Results BHR, respiratory symptoms and their simultaneous occurrence depended on the duration of exposure. FEV1 significantly decreased with duration of exposure and BHR at a preceding visit. This result persisted when adjusting for the effect of BHR at the current visit. The measured exposure levels were not a significant predictor for any outcome. Occupational sensitization was only a predictor of a decline in FEV1 when duration of exposure was not included.Conclusion In flour-exposed industrial bakers, length of exposure and smoking are long-term determinants of BHR and of the decrease in FEV1. BHR at a preceding visit predicted lower FEV1 even when accounting for the effect of BHR at the current visit.
Databáze: OpenAIRE
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