Prevention of Neuromusculoskeletal Frailty in Slow-Aging Ames Dwarf Mice: Longitudinal Investigation of Interaction of Longevity Genes and Caloric Restriction
| Autor: | Andrzej Bartke, Zachary Andrew Rasche, Dustin John Rickman, Oge Arum |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Gerontology Aging media_common.quotation_subject Longevity lcsh:Medicine Male mice Physiology Dwarfism 030209 endocrinology & metabolism Motor Activity Biology Longevity genes Mice 03 medical and health sciences 0302 clinical medicine Hand strength medicine Animals Humans lcsh:Science Musculoskeletal System Caloric Restriction 030304 developmental biology media_common 0303 health sciences Multidisciplinary Hand Strength lcsh:R Body Weight Caloric theory Congenital hypopituitarism medicine.disease Mice Mutant Strains Motor coordination Physical Fitness lcsh:Q Female Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 8, Iss 10, p e72255 (2013) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0072255 |
| Popis: | Ames dwarf (Prop1 (df/df) ) mice are remarkably long-lived and exhibit many characteristics of delayed aging and extended healthspan. Caloric restriction (CR) has similar effects on healthspan and lifespan, and causes an extension of longevity in Ames dwarf mice. Our study objective was to determine whether Ames dwarfism or CR influence neuromusculoskeletal function in middle-aged (82 ± 12 weeks old) or old (128 ± 14 w.o.) mice. At the examined ages, strength was improved by dwarfism, CR, and dwarfism plus CR in male mice; balance/ motor coordination was improved by CR in old animals and in middle-aged females; and agility/ motor coordination was improved by a combination of dwarfism and CR in both genders of middle-aged mice and in old females. Therefore, extension of longevity by congenital hypopituitarism is associated with improved maintenance of the examined measures of strength, agility, and motor coordination, key elements of frailty during human aging, into advanced age. This study serves as a particularly important example of knowledge related to addressing aging-associated diseases and disorders that results from studies in long-lived mammals. |
| Databáze: | OpenAIRE |
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