Contribution of Gluconeogenesis and Glycogenolysis to Hepatic Glucose Production in Acromegaly before and after Pituitary Microsurgery
| Autor: | V. Chandramouli, C. Höybye, W. C. Schumann, Suad Efendic, A. Wajngot, A.-L. Hulting, B. R. Landau |
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| Rok vydání: | 2008 |
| Předmět: |
Adenoma
Blood Glucose Male Microsurgery medicine.medical_specialty Glycogenolysis Hepatic glucose Endocrinology Diabetes and Metabolism Clinical Biochemistry Carbohydrate metabolism Biology Biochemistry Endocrinology Insulin resistance Internal medicine Acromegaly medicine Humans Ingestion Pituitary Neoplasms Insulin-Like Growth Factor I Excess growth hormone Human Growth Hormone Biochemistry (medical) Gluconeogenesis General Medicine Middle Aged medicine.disease Glucose Liver Pituitary Gland Female |
| Zdroj: | Hormone and Metabolic Research. 40:498-501 |
| ISSN: | 1439-4286 0018-5043 |
| DOI: | 10.1055/s-2008-1065322 |
| Popis: | The diabetogenic effect of excess growth hormone (GH) such as that in acromegaly is well known. However, the contribution of the various components to hepatic glucose production (HGP) is not completely understood. In this study we evaluated insulin resistance, HGP, gluconeogenesis (GNG), and glycogenolysis (GLY) in five patients with acromegaly before and after pituitary microsurgery. Insulin resistance was estimated by the HOMA index. HGP was measured using a primed continuous (6,6- 2H2) glucose infusion, and GNG was measured from 2 H enrichment at carbons 2 and 5 of blood glucose on ingestion of 2H2O. The ratio of these enrichments equals the fractional contribution of GNG to HGP, and GLY was calculated as the difference between HGP and GNG. All measurements were performed after 12 hours of fasting. Levels of GH and IGF-I decreased, as did the HOMA index (p |
| Databáze: | OpenAIRE |
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