Zika Virus Changes Methylation of Genes Involved in Immune Response and Neural Development in Brazilian Babies Born With Congenital Microcephaly
| Autor: | Selma M B Jeronimo, Nivia Maria Rodrigues Arrais, Cássio R. M. Souza, Maria do Desterro Soares Brandão Nascimento, Denise Anderson, Jenefer M. Blackwell, Joanna G. Valverde, Josélio Maria Galvão de Araújo, Joao I C F Neri, Timo Lassmann, Rebeca Costa Castelo Branco |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Microcephaly Neurogenesis Cell Cycle Proteins Zika virus 03 medical and health sciences 0302 clinical medicine Immune system Pregnancy 030225 pediatrics medicine Immunology and Allergy Humans Epigenetics Pregnancy Complications Infectious Gene biology Zika Virus Infection Immunity Brain Infant Methylation Zika Virus DNA Methylation biology.organism_classification medicine.disease Virology Cytoskeletal Proteins 030104 developmental biology Infectious Diseases In utero Child Preschool DNA methylation Female Brazil |
| Zdroj: | The Journal of infectious diseases. 223(3) |
| ISSN: | 1537-6613 |
| Popis: | The recent increase in babies born with brain and eye malformations in Brazil is associated with Zika virus (ZIKV) infection in utero. ZIKV alters host DNA methylation in vitro. Using genome-wide DNA methylation profiling we compared 18 babies born with congenital ZIKV microcephaly with 20 controls. We found ZIKV-associated alteration of host methylation patterns, notably at RABGAP1L which is important in brain development, at viral host immunity genes MX1 and ISG15, and in an epigenetic module containing the causal microcephaly gene MCPH1. Our data support the hypothesis that clinical signs of congenital ZIKV are associated with changes in DNA methylation. |
| Databáze: | OpenAIRE |
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