A brief focus on memory cells in transplantation
| Autor: | A. Le Moine, B. Vokaer, Louis-Marie Charbonnier |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Graft Rejection
Transplantation Focus (computing) B-Lymphocytes Isoantigens business.industry T cell T-Lymphocytes Islets of Langerhans Transplantation Kidney Transplantation T-Lymphocytes Regulatory Liver Transplantation medicine.anatomical_structure Diabetes Mellitus Type 1 Immunology Medicine Humans Surgery business Immunologic Memory Immunosuppressive Agents Lung Transplantation |
| Zdroj: | Transplantation proceedings. 41(8) |
| ISSN: | 1873-2623 |
| Popis: | T and B memory cells are critical for host defences against pathogens. However, converging lines of evidence indicate that alloreactive memory T cells can play a detrimental role in the transplantation setting. This emergence of memory cells seems to be facilitated by several induction therapies and immunosuppressive agents, which lead to T cell loss. Herein, we briefly review some clinical and experimental observations from the literature, highlighting the immunological risk associated with enhanced T-cell memory responses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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