Clinical features and treatment outcomes of advanced stage primary hepatic angiosarcoma
| Autor: | Sun Young Rha, Nae Choon Yoo, S. H. Cheon, Young Nyun Park, JaeKyung Roh, Hye Ryun Kim |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Abdominal pain medicine.medical_treatment Hemangiosarcoma Antineoplastic Agents Malignancy Medicine Humans Angiosarcoma Tumor marker Aged Retrospective Studies Chemotherapy business.industry Liver Neoplasms Retrospective cohort study Hematology Middle Aged medicine.disease Chemotherapy regimen Immunohistochemistry Surgery Treatment Outcome Oncology Radiology Sarcoma medicine.symptom business |
| Zdroj: | Annals of oncology : official journal of the European Society for Medical Oncology. 20(4) |
| ISSN: | 1569-8041 |
| Popis: | Background Primary hepatic angiosarcoma is a very rare malignancy with a poor prognosis. While surgical resection has been validated as curative choice, most cases are diagnosed too late for resection. Nonetheless, treatment protocols have not been established and also there are very few reports on the clinical features and treatment outcomes. Patients and methods Among 11 939 patients diagnosed with primary hepatic tumors from January 1985 to December 2007 at two centers, five patients were diagnosed with primary hepatic angiosarcoma. We analyzed patients’ demographics, tumor characteristics, treatment modality, and outcomes using imaging, serology, and pathology. Results All five patients were diagnosed at advanced stage with distant metastases. The most common symptom was abdominal pain. The levels of the tumor markers were within the normal range and serological tests were negative for hepatitis B and C viruses. Two of four patients who received chemotherapy died 6 months. Conclusions A combination of chemotherapy resulted in an improved outcome for two of four patients, suggesting the potential usefulness of palliative chemotherapy to improve survival. This case study may aid in planning chemotherapy for patients with advanced hepatic angiosarcoma. |
| Databáze: | OpenAIRE |
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