Regulation of brain gene expression in honey bees by brood pheromone

Autor: Sandra L. Rodriguez-Zas, Y. Le Conte, Heather A. Adams, Gene E. Robinson, Christina M. Grozinger, Cédric Alaux, Saurabh Sinha
Přispěvatelé: University of Illinois System, Abeilles et Environnement (AE), Institut National de la Recherche Agronomique (INRA)-Avignon Université (AU), Department of Animal Sciences, North Carolina State University [Raleigh] (NC State), University of North Carolina System (UNC), University of Illinois, University of Illinois at Urbana-Champaign [Urbana]
Rok vydání: 2009
Předmět:
0106 biological sciences
Forage (honey bee)
[SDV]Life Sciences [q-bio]
Amino Acid Motifs
HYMENOPTERA
APIFORMES
01 natural sciences
Pheromones
HONEYBEE
Behavioral Neuroscience
Gene expression
Regulatory Elements
Transcriptional
BRAIN
Promoter Regions
Genetic
EXPRESSION GENETIQUE
Regulation of gene expression
Genetics
0303 health sciences
MATURATION COMPORTEMENTALE
Behavior
Animal
Ecology
MOLECULAR BIOLOGY
Bees
CIS-REGULATORY ELEMENT
BEHAVIORAL MATURATION
Up-Regulation
Smell
Neurology
Sex pheromone
behavior and behavior mechanisms
Pheromone
Female
APIDAE
POLLINISATEUR
GENE EXPRESSION
BROOD PHEROMONE
CHEMICAL COMMUNICATION
Down-Regulation
Biology
010603 evolutionary biology
03 medical and health sciences
CERVEAU
Animals
PHEROMONE
Social Behavior
Gene
030304 developmental biology
fungi
APIS MELLIFERA
Feeding Behavior
Honey bee
BIOLOGIE MOLECULAIRE
PHEROMONE DE COUVAIN
Brood
ABEILLE DOMESTIQUE
COMMUNICATION CHIMIQUE
Gene Expression Regulation
POLLINATOR
HONEY BEE
Zdroj: Genes, Brain and Behavior
Genes, Brain and Behavior, Wiley, 2009, 8, pp.309-319. ⟨10.1111/j.1601-183X.2009.00480.x⟩
ISSN: 1601-183X
1601-1848
Popis: International audience; Pheromones are very important in animal communication. To learn more about the molecular basis of pheromone action, we studied the effects of a potent honey bee pheromone on brain gene expression. Brood pheromone (BP) caused changes in the expression of hundreds of genes in the bee brain in a manner consistent with its known effects on behavioral maturation. Brood pheromone exposure in young bees causes a delay in the transition from working in the hive to foraging, and we found that BP treatment tended to upregulate genes in the brain that are upregulated in bees specialized on brood care but downregulate genes that are upregulated in foragers. However, the effects of BP were age dependent; this pattern was reversed when older bees were tested, consistent with the stimulation of foraging by BP in older bees already competent to forage. These results support the idea that one way that pheromones influence behavior is by orchestrating large-scale changes in brain gene expression. We also found evidence for a relationship between cis and BP regulation of brain gene expression, with several cis-regulatory motifs statistically overrepresented in the promoter regions of genes regulated by BP. Transcription factors that target a few of these motifs have already been implicated in the regulation of bee behavior. Together these results demonstrate strong connections between pheromone effects, behavior, and regulation of brain gene expression.
Databáze: OpenAIRE
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