Severe acute abdomen caused by symptomatic Meckel's diverticulum in three children with trisomy 18
| Autor: | Anri Hayashi, Takashi Kusunoki, Oki Furukawa, Minoru Shibata, Fumihito Nozaki, Ikuko Hiejima, Tatsuya Fujii, Tomohiro Kumada |
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| Rok vydání: | 2015 |
| Předmět: |
Pediatrics
medicine.medical_specialty Gastrointestinal bleeding Trisomy Intestinal Volvulus Intussusception (medical disorder) Genetics medicine Humans Genetics (clinical) Abdomen Acute Meckel's diverticulum Gastrointestinal tract business.industry Infant Newborn Infant medicine.disease Meckel Diverticulum Acute abdomen Child Preschool Female medicine.symptom Chromosomes Human Pair 18 Gastrointestinal Hemorrhage business Intussusception Trisomy 18 Syndrome Diverticulum |
| Zdroj: | American Journal of Medical Genetics Part A. 167:2447-2450 |
| ISSN: | 1552-4825 |
| DOI: | 10.1002/ajmg.a.37098 |
| Popis: | Meckel's diverticulum (MD) is the most prevalent congenital anomaly of the gastrointestinal tract and often presents a diagnostic challenge. Patients with trisomy 18 frequently have MD, but the poor prognosis and lack of consensus regarding management for neonates has meant that precise information on the clinical manifestations in infants and children with MD is lacking. We describe the cases of three children with trisomy 18 who developed symptomatic MD. Intussusception was diagnosed in Patient 1, intestinal volvulus in Patient 2, and gastrointestinal bleeding in Patient 3. All three patients underwent surgical treatment and only the Patient 1 died due to pulmonary hypertensive crisis. The other two patients experienced no further episodes of abdominal symptoms. In patients with trisomy 18, although consideration of postoperative complications and prognosis after surgical treatment is necessary, symptomatic MD should carry a high index of suspicion in patients presenting with acute abdomen. |
| Databáze: | OpenAIRE |
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