Predictive values of serum uric acid and alanine-aminotransferase for fatty liver index in montenegrin population
| Autor: | Aleksandra Klisic, Ana Ninic, Nebojsa Kavaric |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
obesity hiperurikemija Population inflamacija 030209 endocrinology & metabolism hyperuricemia digestive system Gastroenterology gojaznost lcsh:Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine masna jetra Medicine lcsh:QD415-436 Hyperuricemia education transaminases fatty liver transam inases Original Paper education.field_of_study Receiver operating characteristic business.industry Serum uric acid Fatty liver Area under the curve nutritional and metabolic diseases medicine.disease Obesity digestive system diseases 3. Good health chemistry inflammation Uric acid 030211 gastroenterology & hepatology business transaminaze |
| Zdroj: | Journal of Medical Biochemistry, Vol 38, Iss 4, Pp 407-417 (2019) Journal of Medical Biochemistry Journal of Medical Biochemistry (2019) 38(4):407-417 |
| ISSN: | 1452-8266 1452-8258 |
| Popis: | Alanine-aminotransferase (ALT) and uric acid cut-off levels used in non-alcoholic fatty liver disease (NAFLD) diagnosis are advised to be lowered. Due to contradictory results on the utility of both these biomarkers for NAFLD screening, we aimed to determine their cut-off levels that can be applied to Montenegrin population with the fatty liver disease.A total of 771 volunteers were enrolled. A fatty liver index (FLI) score ≥60 was used as proxy of NAFLD. The receiver operating characteristic curve analysis with the area under the curve (AUC) was used to determine the cut-off values of ALT and uric acid associated with FLI ≥60.ALT was independent predictor of FLI in both men and women, whereas serum uric acid was its independent predictor only in women. Lower cut-off levels of ALT are associated with the increased prevalence of NAFLD [i.e., ALT was 19 IU/L (AUC=0.746, sensitivity 63%, specificity 72%, P0.001) in women and 22 IU/L (AUC=0.804, sensitivity 61%, specificity 95%, P0.001) in men]. The cut-off value for uric acid was 274 μmol/L (AUC=0.821, sensitivity 68%, specificity 82%, P0.001) in women.Lower cut-off levels of ALT in both genders, and serum uric acid in females, can be reliable predictors of the FLI.Preporuka skorijih studija je da cut-off vrednosti alanin-aminotransferaze (ALT) i mokraćne kiseline budu niže u cilju dijagnostikovanja nealkoholne steatoze jetre. S obzirom na postojanje oprečnih rezultata kada su u pitanju ovi biomarkeri u cilju skrininga na nealkoholnu steatozu jetre, cilj ove studije je bio da se odrede cut-off vrednosti koje bi mogle biti primenjive u crnogorskoj populaciji za dijagnostiku ovog poremećaja.Istraživanje je obuhvatilo ukupno 771 dobrovoljca. Indeks masne jetre (engl. fatty liver index-FLI) ≥60 je korišten za dijagnostikovanje nealkoholne steatoze jetre. ROC analiza i površina ispod krive (engl. area under the curve-AUC) su korišteni za određivanje cut-off vrednosti ALT i mokraćne kiseline, koji su povezani sa FLI ≥60.ALT je nezavisan prediktor FLI kod oba pola, dok je mokraćna kiselina nezavisan prediktor masne jetre samo kod žena. Takođe, niže cut-off vrednosti ALT su povezane sa većom prevalencom pojave masne jetre [za ALT kod žena vrednost je 19 IU/L (AUC=0,746, senzitivnost 63%, specifičnost 72%, P0,001), a kod muškaraca je 22 IU/L (AUC=0,804, senzitivnost 61%, specifičnost 95%, P0,001)]. Cut-off vrednost za mokraćnu kiselinu za pojavu masne jetre kod žena je 274 μmol/L (AUC=0,821, senzitivnost 68%, specifičnost 82%, P0,001).Niže cut-off vrednosti ALT kod oba pola, kao i niže vrednosti mokraćne kiseline kod žena, mogu biti pouzdani prediktori za pojavu masne jetre. |
| Databáze: | OpenAIRE |
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