Expression of the inflammatory chemokines CCL2, CCL5 and CXCL2 and the receptors CCR1-3 and CXCR2 in T lymphocytes from mammary tumor-bearing mice
| Autor: | Kathleen Guthrie, Ramon Garcia-Areas, Marta Torroella-Kouri, Stephania Libreros, Michael F. Criscitiello, Jennifer L. Owen, Vijaya Iragavarapu-Charyulu |
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| Rok vydání: | 2010 |
| Předmět: |
CCR1
Chemokine Receptors CCR2 Receptors CCR3 T-Lymphocytes Immunology CCR3 Chemokine CXCL2 Receptors CCR1 Gene Expression Biology Adenocarcinoma CCL7 Receptors Interleukin-8B Article Chemokine receptor Mice Lymphocytes Tumor-Infiltrating T-Lymphocyte Subsets Cell Line Tumor Animals CXC chemokine receptors RNA Messenger RNA Neoplasm Chemokine CCL5 Chemokine CCL2 Mammary tumor Tumor microenvironment Mice Inbred BALB C Mammary Neoplasms Experimental Recombinant Proteins Cancer research biology.protein Female Receptors Chemokine Chemokines Inflammation Mediators |
| Zdroj: | Cellular immunology. 270(2) |
| ISSN: | 1090-2163 |
| Popis: | Chemokines and their receptors have been studied in several solid tumor models as mediators of inflammation. In turn, inflammation has been implicated in the promotion and progression of tumors, and as such, chemokines have been proposed as novel molecular targets for chemotherapy. While the expression of these molecules has been described in tumor cells, endothelial cells, macrophages, and neutrophils, less attention has been paid to the expression profile of these molecules by T lymphocytes in the periphery or infiltrating the tumor. Using the D1-DMBA-3 murine mammary adenocarcinoma model, we aimed to better characterize the differential expression of chemokines and/or their receptors in the host and in the tumor microenvironment, and specifically, in the T cells of tumor-bearing mice compared to normal control animals. We found that T lymphocytes from tumor-bearing mice express the pro-inflammatory chemokines, CCL2, CCL5, and CXCL2, as well as the chemokine receptors, CCR1, CCR2, CCR3 and CXCR2. |
| Databáze: | OpenAIRE |
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