Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation
| Autor: | Luqing Shang, Zhang Xue, Zheng Yin, Peng Wang, Yun-Ping Li, Hui-Hui Yuan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
lycorine derivatives
anticancer synthesis Stereochemistry Pharmaceutical Science Antineoplastic Agents Article Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound Structure-Activity Relationship lcsh:Organic chemistry Drug Discovery Liliaceae Structure–activity relationship Humans Physical and Theoretical Chemistry Amaryllidaceae Alkaloids Biological evaluation Cell Proliferation Chemistry Cell growth Plant Extracts Alkaloid Organic Chemistry Lycorine HCT116 Cells Combinatorial chemistry In vitro Phenanthridines Chemistry (miscellaneous) Molecular Medicine Amine gas treating |
| Zdroj: | Molecules; Volume 19; Issue 2; Pages: 2469-2480 Molecules, Vol 19, Iss 2, Pp 2469-2480 (2014) Molecules |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules19022469 |
| Popis: | Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer cell lines, including A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60. The results indicated that compounds bearing diverse amine substituents at the C-2 position demonstrated good anticancer activities. The selectivity towards different cancer cell lines of the synthesized derivatives is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|