Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biocompatible PLGA-PEG nanocarriers for early detection and treatment of tumours
| Autor: | Xiaoming Zheng, Longbao Feng, Nan Li, Rongpu Liang, Zikai Cai, Li Deng, Rui Guo, Chenghua Liang, Bo Wei |
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| Rok vydání: | 2019 |
| Předmět: |
Drug
media_common.quotation_subject Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) Plga peg Early detection macromolecular substances 02 engineering and technology 03 medical and health sciences 0302 clinical medicine medicine Doxorubicin media_common Chemistry technology industry and agriculture food and beverages Cancer General Medicine 021001 nanoscience & nanotechnology medicine.disease 030220 oncology & carcinogenesis Co encapsulation Cancer research Nanocarriers 0210 nano-technology Fe3o4 nanoparticles Biotechnology medicine.drug |
| Zdroj: | Artificial Cells, Nanomedicine, and Biotechnology. 47:4211-4221 |
| ISSN: | 2169-141X 2169-1401 |
| DOI: | 10.1080/21691401.2019.1687500 |
| Popis: | At present, cancer is the first cause of death for humans, but early detection and treatment can help improve prognoses and reduce mortality. However, further development of carrier-assistant drug delivery systems (DDSs) is retarded by the aspects such as the low drug-carrying capacity, carrier-induced toxicity and immunogenicity, complex synthesis manipulation. The development of nanoscale drug delivery systems (NDDS) have been rapidly developed to address these issues. In this article, we used PLGA-PEG with good biocompatibility to encapsulate Fe3O4 nanoparticles (a magnetic resonance imaging contrast agent) and DOX (an antitumour drug) via the emulsion-solvent evaporation method, aimed at achieving a dual function of the early detection and the treatment of mammary cancer. The results showed that the Fe3O4/DOX/PLGA-PEG nanoparticles had a relatively uniform size, a high carrier rate of Fe3O4 and high encapsulation efficiency of DOX, and a relatively high activity of released DOX within 120 h. In addition, in vitro studies showed that the Fe3O4/DOX/PLGA-PEG nanoparticles were cytocompatibility in NIH 3T3 fibroblast cells culture study while had a special effect on destroying human breast cancer MCF-7 cells compared with pure DOX solution. In vitro studies revealed that the Fe3O4/DOX/PLGA-PEG enabled enhanced T2 contrast magnetic resonance. Overall, our multifunctional Fe3O4/DOX/PLGA-PEG nanoparticles, composed of biocompatible substances and therapeutic/imaging materials, have great potential for the early detection of cancer and accurate drug delivery via the dynamic monitoring using MRI. |
| Databáze: | OpenAIRE |
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