The stimulatory effect of calcium on the synthesis of cartilage proteoglycan
| Autor: | Herbert J. Shulman, Annette Opler |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
medicine.medical_specialty
Biophysics chemistry.chemical_element Chick Embryo Calcium Sulfur Radioisotopes Biochemistry chemistry.chemical_compound Somatomedins Internal medicine Negative charge medicine Animals Humans Magnesium Molecular Biology Glycosaminoglycans Calcium metabolism biology Cartilage Cell Biology Spine carbohydrates (lipids) Endocrinology medicine.anatomical_structure Proteoglycan chemistry Puromycin biology.protein Proteoglycans |
| Zdroj: | Biochemical and biophysical research communications. 59(3) |
| ISSN: | 0006-291X |
| Popis: | Summary Calcium stimulates the uptake of [ 35 S] SO 4 into cartilage at physiological concentration for ionized calcium. This effect can be blocked by puromycin, indicating calcium stimulates the synthesis of proteoglycan. It is proposed that this effect is mediated by alteration of the negative charge density of the polyanionic proteoglycan. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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