Strain Estimation of the Murine Right Ventricle Using High-Frequency Speckle-Tracking Ultrasound
| Autor: | Craig J. Goergen, Frederick W. Damen, Kristiina L. Aasa, Melissa Yin, Conner C. Earl, Sarah K. Burris |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Acoustics and Ultrasonics
Longitudinal strain Heart Ventricles Ventricular Dysfunction Right Biophysics Article Free wall Mice Speckle pattern medicine Strain estimation Animals Radiology Nuclear Medicine and imaging Ultrasonography Radiological and Ultrasound Technology Strain (chemistry) business.industry Ultrasound Heart Rats Standard error medicine.anatomical_structure Echocardiography Ventricle Nuclear medicine business |
| Zdroj: | Ultrasound Med Biol |
| ISSN: | 0301-5629 |
| Popis: | Right ventricular (RV) strain measurements from ultrasound via speckle-tracking techniques are being used more frequently as a non-invasive diagnostic tool for a variety of cardiopulmonary pathologies. However, despite the clinical utility of ultrasound RV strain measurements, quantification of RV strain in rodents remains difficult owing to unique image artifacts and non-standardized methodologies. We demonstrate here a simple approach for measuring RV strain in both mice and rats using high-frequency ultrasound and automated speckle tracking. Our results show estimated peak RV free-wall longitudinal strain values (mean ± standard error of the mean) in mice (n = 15) and rats (n = 5) of, respectively, −10.38% ± 0.4% and −4.85% ± 0.42%. We further estimated the 2-D Green–Lagrange strain within the RV free wall, with longitudinal components estimated at −5.7% ± 0.48% in mice and −2.1% ± 0.28% in rats. These methods and data may provide a foundation for future work aimed at evaluating murine RV strain levels in different disease models. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|