Aldosterone Escape With Diuretic or Angiotensin-Converting Enzyme Inhibitor/Angiotensin II Receptor Blocker Combination Therapy in Patients With Mild to Moderate Hypertension
| Autor: | Antonio Coca, Eduardo Arantes Nogueira, Juan Carlos Yugar-Toledo, Samira Ubaid-Girioli, Silvia Elaine Ferreira-Melo, Heitor Moreno, Leoni Adriana de Souza |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Angiotensin receptor Endocrinology Diabetes and Metabolism Aldosterone escape Tetrazoles Angiotensin-Converting Enzyme Inhibitors Plasma renin activity chemistry.chemical_compound Hydrochlorothiazide Irbesartan Tetrahydroisoquinolines Internal medicine Internal Medicine Humans Medicine Diuretics Aldosterone Original Paper biology business.industry Biphenyl Compounds Quinapril Angiotensin-converting enzyme Middle Aged Endocrinology chemistry Hypertension biology.protein Drug Therapy Combination Female Cardiology and Cardiovascular Medicine business Angiotensin II Type 1 Receptor Blockers medicine.drug |
| Zdroj: | J Clin Hypertens (Greenwich) |
| ISSN: | 1524-6175 |
| DOI: | 10.1111/j.1751-7176.2007.tb00091.x |
| Popis: | Renin-angiotensin-aldosterone system (RAAS) hyperactivity is implicated in the development of hypertension and progressive damage in target organs. Chronic inhibition of the RAAS or use of thiazide-type diuretics may trigger an aldoster-one escape. The aim of this study was to assess this phenomenon in hypertensive patients treated with thiazide-type diuretics (hydrochlorothiazide [HCTZ]) or single or double blockade of the RAAS (irbesartan [IRBE], quinapril [QUIN], and IRBE+QUIN). Blood pressure levels were obtained by 24-hour ambulatory blood pressure monitoring. Plasma renin activity and aldosterone levels were determined by immunoradiometric assay. Blood pressure level was normalized in the 4 treatment groups; the HCTZ and IRBE+QUIN groups showed an increased plasma aldosterone level after 12 weeks (9.1+/-2.2 to 14.1+/-1.4 and 6.9+/-1.9 to 12.9+/-2.3 ng/dL, respectively; P |
| Databáze: | OpenAIRE |
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