Quantification of global and regional renal blood flow with electron beam computed tomography
| Autor: | Lahera, Sanchez Fueyo A, Juan C. Romero, John A. Rumberger, Malcolm R. Bell, Lilach O. Lerman, Sheedy Pf nd |
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| Rok vydání: | 1994 |
| Předmět: |
Electron Beam Computed Tomography
Kidney Cortex Vasodilation Computed tomography Bradykinin Renal Circulation Dogs Internal Medicine Medicine Animals Kidney Kidney Medulla biology medicine.diagnostic_test business.industry Fissipedia Blood flow biology.organism_classification EMF measurement medicine.anatomical_structure Renal blood flow business Nuclear medicine Tomography X-Ray Computed Algorithms |
| Zdroj: | American journal of hypertension. 7(9 Pt 1) |
| ISSN: | 0895-7061 |
| Popis: | Alterations in renal blood flow distribution may occur in a variety of pathophysiologic situations; however, quantification of global and regional renal blood flows has been limited because of the lack of reliable, noninvasive techniques. To determine the feasibility of flow measurements with electron-beam computed tomography (EBCT), six anesthetized dogs were scanned by EBCT during basal conditions, after renal vasodilation, and at recovery. Flow (mL/min/cm3 tissue) was calculated from EBCT-derived time-density curves using three different algorithms and compared with simultaneously obtained electromagnetic flow (EMF) probe measurements after indexing to EBCT-derived renal volume. EBCT-determined flow correlated well with EMF measurements regardless of the algorithm used. An algorithm using the area under the time-density curve was concluded to be the most suitable for calculation of renal blood flow; it correlated with EMF as EBCT flow = 44.5 + 1.05 EMF (r = 0.885, SEE = 31.2 mL/min, P < .0001). Consistent overestimation of flow by EBCT resulted probably from retention of contrast media in the renal parenchyma. EMF showed an increase of 20 +/- 10% in renal blood flow after vasodilation. EBCT-derived global, cortical, and medullary flows increased by 33.8 +/- 10.3%, 24.8 +/- 17.8%, and 99.0 +/- 73.8%, respectively. In conclusion, EBCT was found feasible for credible quantitation of renal blood flow in the physiologic range studied. |
| Databáze: | OpenAIRE |
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