FRAX-based fracture probabilities in South Africa
| Autor: | S.L. Brown, Ozayr Mohamed, Nicholas C. Harvey, Eugene V. McCloskey, Johannes D. Jordaan, John A. Kanis, Bilkish Cassim, Mkhululi Lukhele, Pariva Chutterpaul, Farhanah Paruk, Magda Conradie, Mattias Lorentzon, Helena Johansson, Sapna S. Dela, Enwu Liu, Asgar Ali Kalla, Liesbeth Vandenput |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
FRAX Epidemiology Osteoporosis Standard score Risk Assessment Hip fracture South Africa Bone Density Risk Factors Medicine Humans Orthopedics and Sports Medicine Risk factor Femoral neck Aged 80 and over business.industry Femur Neck Hip Fractures Mortality rate Incidence (epidemiology) Middle Aged medicine.disease Fracture probability medicine.anatomical_structure Original Article Female business Osteoporotic Fractures Demography |
| Zdroj: | Archives of Osteoporosis |
| ISSN: | 1862-3522 |
| Popis: | Summary The hip fracture rates in South Africa were used to create ethnic-specific FRAX® models to facilitate fracture risk assessment. Introduction The aim of this study was to develop FRAX models to compute the 10-year probability of hip fracture and major osteoporotic fracture and assess their potential clinical application. Methods Age- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for the White, Black African, Coloured and Indian population of South Africa. Age-specific 10-year probabilities of a major osteoporotic fracture were calculated in women to determine fracture probabilities at a femoral neck T score of -2.5 SD, or those equivalent to a woman with a prior fragility fracture. Fracture probabilities were compared with those from selected countries. Results Probabilities were consistently higher in Indian than in Coloured men and women, in turn, higher than in Black South Africans. For White South Africans, probabilities were lower than in Indians at young ages up to the age of about 80 years. When a BMD T score of −2.5 SD was used as an intervention threshold, FRAX probabilities in women age 50 years were approximately 2-fold higher than in women of the same age but with an average BMD and no risk factors. The increment in risk associated with the BMD threshold decreased progressively with age such that, at the age of 80 years or more, a T score of −2.5 SD was no longer a risk factor. Probabilities equivalent to women with a previous fracture rose with age and identified women at increased risk at all ages. Conclusions These FRAX models should enhance accuracy of determining fracture probability amongst the South African population and help guide decisions about treatment. |
| Databáze: | OpenAIRE |
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