Higher prevalence of cancer related mutations 1762T/1764A and PreS deletions in hepatitis B virus (HBV) isolated from HBV/HIV co-infected compared to HBV-mono-infected Chinese adults
| Autor: | Li-Ping Hu, Shujia Liang, Xiang He, Hui-Hua Jia, Zhong-Liao Fang, Qing-Li Yang, Qin-Yan Chen, Anna Kramvis, Chao Wang, Kai-Wen Li |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine China Hepatitis B virus Cancer Research Genotype Combination therapy HIV Infections Biology medicine.disease_cause 03 medical and health sciences Liver disease 0302 clinical medicine Asian People Virology Prevalence medicine Humans Phylogeny Aged Sequence Deletion Hepatitis B Surface Antigens Coinfection virus diseases Cancer Promoter Middle Aged Viral Load Hepatitis B medicine.disease digestive system diseases CD4 Lymphocyte Count 030104 developmental biology Infectious Diseases Hepatocellular carcinoma DNA Viral Mutation Immunology Female 030211 gastroenterology & hepatology Viral load |
| Zdroj: | Virus Research. 227:88-95 |
| ISSN: | 0168-1702 |
| Popis: | In the era of combination therapy for human immunodeficiency virus (HIV), liver disease including hepatocellular carcinoma (HCC), are the major causes of death for patients co-infected with hepatitis B virus (HBV) and HIV. However, the mechanisms remain obscure. We aimed to determine whether HCC-related HBV mutations including 1762T/1764A double mutation and pre-S deletions occur more frequently in HBV/HIV co-infected individuals compared to HBV mono-infected individuals. In this study, the basic core promoter (BCP) and the preS/S regions of HBV isolated from 61 pairs of HBV/HIV co-infected and HBV mono-infected participants were analyzed. We found that the prevalence of HBV isolates with 1762T/1764A and/or preS deletion mutations was 37.7% (95% CI: 29.1-46.3). The prevalence of these mutations in HBV/HIV co-infected group (52.5%, 95% CI: 40.0-65.0) was significantly higher than in the HBV mono-infected group (23.0%, 95% CI: 12.4-33.6) (X2=11.307, P |
| Databáze: | OpenAIRE |
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