Effects of High-Salt Diet on the Activity of Angiotensin-Converting Enzyme and Generation of Reactive Oxygen Species in Rat Aorta
Autor: | L. N. Kublik, T. V. Arutyunyan, Vera V. Shaposhnikova, Yu. N. Korystov, A. F. Korystova, M. Kh. Levitman |
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Rok vydání: | 2014 |
Předmět: |
Male
medicine.medical_specialty Sodium chemistry.chemical_element Blood Pressure Peptidyl-Dipeptidase A General Biochemistry Genetics and Molecular Biology Renin-Angiotensin System Internal medicine medicine.artery Blood plasma medicine Animals Rats Wistar Sodium Chloride Dietary chemistry.chemical_classification Reactive oxygen species Aorta biology Angiotensin-converting enzyme General Medicine Salt diet Enzyme assay Diet Rats Endocrinology Enzyme chemistry cardiovascular system biology.protein Reactive Oxygen Species |
Zdroj: | Bulletin of Experimental Biology and Medicine. 156:763-767 |
ISSN: | 1573-8221 0007-4888 |
DOI: | 10.1007/s10517-014-2444-x |
Popis: | The dynamics of angiotensin-converting enzyme activity in the aorta and blood plasma and generation of ROS in the aorta were studied in rats subjected to two high-salt diets (0.4% and 1% NaCl solutions). During high-salt diets, activity of angiotensin-converting enzyme in the aorta progressively decreased to the minimal during week 1 and remained lower than control level for 1 month. Both diets were followed by a decrease in ROS concentration in the aorta, and this effect was more pronounced when the dosage of salt increased. ROS level in the aorta varied similarly during both diets, but the amplitude of the response was significantly higher in rats receiving 0.4% salt solution. ROS amount in the aorta during high-salt diets differed from the control level and depended from salt dosage and the duration of administration. |
Databáze: | OpenAIRE |
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