30-days effects of vildagliptin on vascular function, plasma viscosity, inflammation, oxidative stress, and intestinal peptides on drug-naïve women with diabetes and obesity: a randomized head-to-head metformin-controlled study
| Autor: | Priscila A. Maranhão, Luiz Guilherme Kraemer-Aguiar, Diogo G. Panazzolo, José Firmino Nogueira Neto, Maria das Graças Coelho de Souza, Alessandra Schiapaccassa, Eliete Bouskela |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Endothelium Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine Diabetes mellitus Internal Medicine medicine Vildagliptin Obesity lcsh:RC620-627 Adiponectin business.industry Insulin Research Oral therapies Diabetes medicine.disease Metformin lcsh:Nutritional diseases. Deficiency diseases Endocrinology medicine.anatomical_structure business medicine.drug |
| Zdroj: | Diabetology & Metabolic Syndrome Diabetology & Metabolic Syndrome, Vol 11, Iss 1, Pp 1-9 (2019) |
| ISSN: | 1758-5996 |
| Popis: | Background Obesity is the main risk factor for diabetes and excessive visceral fat triggers low-grade inflammatory process, mediated by activation and release of cytokines and high flow of free fatty acids that contribute to insulin resistance, increased oxidative stress, and impaired endothelial function. Metformin and vildagliptin have known vasculoprotective actions, but the value of these drugs on drug-naïve diabetic patients during 30 days use warrants investigation. Our purpose was to observe their effects on endothelial function, oxidative stress, inflammatory biomarkers, and plasma viscosity. Methods 38 women with obesity and type 2 diabetes drug-naïve, aged between 19 and 50 years, BMI ≥ 30 kg/m2, were recruited and subjected to measurements of endothelial function, nutritive skin microvascular reactivity, plasma viscosity, inflammatory and oxidative stress biomarkers at baseline and randomized 1:1 to ingest metformin (850 mg twice/day) or vildagliptin (50 mg twice/day) during 30 days, and then, re-evaluated. Results No differences between groups were noticed at baseline. After treatment, vildagliptin promoted an improvement on endothelial-dependent and -independent vasodilatations, at arteriole level, while metformin resulted in improved nutritive microvascular reactivity, at the capillary level. Intragroup analysis showed that vildagliptin reduced insulin, C-peptide and oxidized LDL, and increased adiponectin and glucagon-like peptide-1 while metformin reduced weight, plasma glucose, total cholesterol, HDL-c, LDL-c, and dipeptidyl peptidase-4 activity, with an unexpected increase on tumor necrosis factor-α. No significant difference in plasma viscosity was noted. Conclusions In the vascular beds investigated, both drugs used for only 30 days improved endothelial function, through distinct, and possibly, complementary mechanisms on drug-naïve diabetic women. Trial Registration ClinicalTrials.gov: NCT01827280 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink