Chromosome 5 and 7 Abnormalities in Oncology Personnel Handling Anticancer Drugs
| Autor: | Melissa A. McDiarmid, Marc Oliver, Carmen P. Escalante, Tracy Roth, M. E. Bonnie Rogers |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Oncology Drug medicine.medical_specialty media_common.quotation_subject Antineoplastic Agents Medical Oncology Occupational Exposure Surveys and Questionnaires Internal medicine medicine Humans media_common Chromosome Aberrations Chromosome 7 (human) Polymorphism Genetic business.industry Public Health Environmental and Occupational Health Chromosome Hazardous drugs Middle Aged Peripheral blood Chromosomes Human Pair 5 Female Occupational exposure business Chromosomes Human Pair 7 medicine.drug |
| Zdroj: | Journal of Occupational & Environmental Medicine. 52:1028-1034 |
| ISSN: | 1076-2752 |
| DOI: | 10.1097/jom.0b013e3181f73ae6 |
| Popis: | To determine the frequency of "signature" chromosomal abnormalities in oncology workers handling anticancer drugs.Peripheral blood from health care personnel (N = 109) was examined with probes for targets on chromosomes 5, 7, and 11. The effect of drug-handling frequency on chromosome abnormalities was assessed.An excess of structural (0.18 vs 0.02; P = 0.04) and total abnormalities (0.29 vs 0.04; P = 0.01) of chromosome 5 was observed in the high-exposure group compared with the unexposed. Increased incidence rate ratios (IRRs) for abnormalities of chromosome 5 (IRR = 1.24; P = 0.01) and for either chromosome 5 or 7 (IRR = 1.20; P = 0.01) were obtained at 100 handling events. Effect sizes were augmented 2- to 4-fold when alkylating agent handling alone was considered.Biologically important exposure to genotoxic drugs is apparently occurring in oncology work settings despite reported use of safety practices. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|