Aspirin-induced gastrointestinal microbleeding in dogs
| Autor: | Barrie M. Phillips |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Male
Pharmacology Analysis of Variance Aspirin Time Factors Dose-Response Relationship Drug business.industry Body Weight Drug administration Toxicology Iron Isotopes Feces Dogs Blood loss Occult Blood Anesthesia medicine Animals ASPIRIN TABLETS Gastrointestinal Hemorrhage business Whole blood medicine.drug |
| Zdroj: | Toxicology and Applied Pharmacology. 24:182-189 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/0041-008x(73)90138-5 |
| Popis: | 59Fe-labeled ferrous sulfate was administered iv to 12 male dogs, and gastrointestinal microbleeding was determined by comparison of the 59Fe specific activities of 24-hr stool collections and of whole blood. During a 69-day period following injection of 59Fe, the dogs received 0, 32.5, 65, or 97.5 mg/kg aspirin po in gelatin capsules twice daily during four 7-day treatment periods (each of which was preceded by a 7-day period of no treatment) in complete changeover fashion. Over this range (approximately equivalent to 1, 2 or 3 five-grain aspirin tablets twice daily), aspirin increased gastrointestinal microbleeding in a dose-dependent manner. This response to aspirin was reflected in increased fecal blood loss beginning on the first day of drug administration, in contrast to the response in humans, which is generally delayed 24 hr. The dog does not become refractory to this effect of aspirin during 7-day treatment periods or during alternating control and aspirin treatment periods. It was concluded that the dog may be a suitable species for the evaluation of the effect of aspirin formulations on gastrointestinal microbleeding. |
| Databáze: | OpenAIRE |
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