An acrylic reline resin loaded with chlorhexidine: Insights on drug release
Autor: | Cristina Bettencourt Neves, Marina Feliz, Ana Bettencourt, Lídia Gonçalves, Catarina Sousa |
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Rok vydání: | 2016 |
Předmět: |
Drug
Saliva media_common.quotation_subject Antifungal drug Dentistry Context (language use) 02 engineering and technology Estomatite protética Denture stomatitis 03 medical and health sciences 0302 clinical medicine Resina acrílica de rebasamento medicine Controlled release Candida albicans General Dentistry media_common Chromatography biology Chemistry business.industry Chlorhexidine Libertação controlada Acrylic reline resin 030206 dentistry 021001 nanoscience & nanotechnology biology.organism_classification 3. Good health Clorhexidina Drug release Surgery 0210 nano-technology business medicine.drug |
Zdroj: | Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial. 57(3):125-131 |
ISSN: | 1646-2890 |
DOI: | 10.1016/j.rpemd.2016.04.001 |
Popis: | Objectives Dental-biomaterials loaded with drugs are a promising strategy for local infection treatment. In this context, some studies suggest the incorporation of chlorhexidine (CHX), as an antifungal drug, in acrylic reline resins for the treatment of Candida albicans associated dental infections. The purpose of this study was to evaluate the release of CHX from one acrylic reline resin, Kooliner (K). Furthermore, the effect of different media conditions and the drug loading on the CHX release was assessed. Methods Resin specimens were prepared from a hard denture reline material based on poly(ethylmethacrylate) (PEMA) and isobutylmethacrylate (IBMA) containing 2.5, 5.0, 7.5 and 10 wt% of CHX. The CHX-loaded resins were incubated in water and artificial saliva (at pH 7) for up to 28 days at 37 °C. Chlorhexidine content was determined by UV-spectroscopy (255 nm). Results CHX release was influenced by media composition and drug loading. CHX demonstrated a similar release profile in the two media, however the water showed the higher amount of release in comparison with the inorganic mimetic saliva. CHX release increased proportionally to the concentration of the CHX added, in a linear trend line. Moreover, a high percentage of CHX was not release up to 28 days. Conclusions Despite the limitations of the present investigation, results from the present study highlight the need of evaluating drug release not only in water but also in saliva. Strategies that increase the complete release of drug from the material should be investigated in order to prevent the development of multiresistant strains. |
Databáze: | OpenAIRE |
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