Successful in vitro fertilization in women with Fontan physiology
| Autor: | Sara L. Partington, Yuli Y. Kim, Lisa D. Levine, Clarisa R. Gracia, Suneeta Senapati, Emily Ruckdeschel, Prakash A. Patel |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
0301 basic medicine Infertility medicine.medical_specialty Pregnancy Rate media_common.quotation_subject medicine.medical_treatment Reproductive medicine Volume overload Oocyte Retrieval Fertility Fertilization in Vitro Miscarriage 03 medical and health sciences 0302 clinical medicine Ovulation Induction Pregnancy Genetics medicine Humans Cardiac Surgical Procedures Assisted Reproduction Technologies Genetics (clinical) media_common 030219 obstetrics & reproductive medicine In vitro fertilisation Obstetrics business.industry Obstetrics and Gynecology General Medicine medicine.disease 030104 developmental biology Reproductive Medicine Cardiovascular Diseases Heart failure Female business Developmental Biology |
| Zdroj: | J Assist Reprod Genet |
| ISSN: | 1573-7330 1058-0468 |
| DOI: | 10.1007/s10815-020-01969-2 |
| Popis: | PURPOSE: Patients with single ventricle anatomy palliated with Fontan operation are at risk for thromboembolism, arrhythmia, and heart failure rendering pregnancy high risk or even contraindicated. Infertility and high rates of first trimester miscarriage are not uncommon. In vitro fertilization (IVF) with or without gestational surrogacy can be an option, but poses risks during ovarian stimulation, oocyte retrieval, and the post-procedural period. We present six cases of women with complex congenital heart disease status post Fontan operation who underwent successful IVF. METHODS: Case series from a single-center tertiary care setting. RESULTS: Indications for referral were cardiac or fertility concerns for pregnancy of the congenital cardiologist. One woman had mild volume overload after oocyte retrieval requiring furosemide and one experienced post-operative colitis. There were no thrombotic complications. CONCLUSIONS: A multidisciplinary team-based approach can result in successful oocyte retrieval and IVF in women with complex congenital heart disease and Fontan physiology. |
| Databáze: | OpenAIRE |
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