Pharyngeal Microbial Signatures Are Predictive of the Risk of Fungal Pneumonia in Hematologic Patients
| Autor: | Luca Facchini, Luigina Romani, Daniela Valente, Antonio Spadea, Katerina Coufalikova, Lukas Englmaier, Katia Codeluppi, Monica Borghi, Matteo Puccetti, Teresa Zelante, Angelica Spolzino, Zdenek Spacil, Giulia Dragonetti, Melissa Palmieri, Francesco Merli, Gianpaolo Nadali, Giuseppe Lomurno, Claudio Costantini, Emilia Nunzi, Francesco Marchesi, Roberta Spaccapelo, Franco Aversa, Marina M. Bellet, Vincenzo Nicola Talesa, Enzo Acerbi, Stefano Giovagnoli, Lorella Melillo, Giorgia Renga, Livio Pagano, Gessica Marchesini |
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| Přispěvatelé: | Singapore Centre for Environmental Life Sciences and Engineering |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Indole-3aldehyde Antifungal Agents Hematological malignancies invasive fungal infection airway microbiome metabolomics tryptophan indole-3-aldehyde antibiotics Antibiotics invasive fungal infection antibiotics Hematological malignancies Mice 0302 clinical medicine Risk Factors Antimicrobial stewardship airway microbiome biology Microbiota Biological sciences [Science] Host-Associated Microbial Communities metabolomics 3. Good health Infectious Diseases Hematologic Neoplasms 030220 oncology & carcinogenesis Metabolic profile medicine.drug_class Hematological Malignancies Immunology Risk Assessment Microbiology 03 medical and health sciences medicine Animals Humans tryptophan Clostridiales Airway Microbiome Bacteroidetes indole-3-aldehyde Pneumonia biology.organism_classification Fungal pneumonia medicine.disease Hematologic Diseases Disease Models Animal Settore MED/15 - MALATTIE DEL SANGUE 030104 developmental biology Mycoses Murine model Metagenome Pharynx Parasitology Metagenomics Dysbiosis |
| Zdroj: | Infect Immun |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.00105-21 |
| Popis: | The ability to predict invasive fungal infections (IFI) in patients with hematological malignancies is fundamental for successful therapy. Although gut dysbiosis is known to occur in hematological patients, whether airway dysbiosis also contributes to the risk of IFI has not been investigated. Nasal and oropharyngeal swabs were collected for functional microbiota characterization in 173 patients with hematological malignancies recruited in a multicenter, prospective, observational study and stratified according to the risk of developing IFI. A lower microbial richness and evenness were found in the pharyngeal microbiota of high-risk patients that were associated with a distinct taxonomic and metabolic profile. A murine model of IFI provided biologic plausibility for the finding that loss of protective anaerobes, such as Clostridiales and Bacteroidetes, along with an apparent restricted availability of tryptophan, is causally linked to the risk of IFI in hematologic patients and indicates avenues for antimicrobial stewardship and metabolic reequilibrium in IFI. This work was supported by FunMeta Project (ERC-2011-AdG 293714), MicroTher(ERC-2018-PoC-813099), and Gilead (IN-IT-131-4525-518872.9) to L.R. and the GrantAgency of the Czech Republic (GACR No 17-24592Y) and the Czech Ministry ofEducation, Youth and Sports (CETOCOEN PLUS CZ.02.1.01/0.0/0.0/15_003/0000469;LM2015051 and CETOCOEN EXCELLENCE Teaming 2 project CZ.02.1.01/0.0/0.0/18_046/0015975; and Horizon2020 project 857560) to Z.S. |
| Databáze: | OpenAIRE |
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