The time course of the humoral immune response to rhinovirus infection
| Autor: | W. S. Barclay, W. Al-Nakib, D. A. J. Tyrrell, P.G. Higgins |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
Immunoglobulin A Rhinovirus Epidemiology Common Cold Enzyme-Linked Immunosorbent Assay Antibodies Viral medicine.disease_cause Neutralization Immunoglobulin G Immune system stomatognathic system Neutralization Tests Recurrence otorhinolaryngologic diseases medicine Humans biology Inoculation virus diseases Common cold medicine.disease Virology Infectious Diseases Carrier State Immunology biology.protein Antibody Research Article circulatory and respiratory physiology |
| Zdroj: | Epidemiology and Infection. 103:659-669 |
| ISSN: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s095026880003106x |
| Popis: | SUMMARYThe specific humoral immune response of 17 volunteers to infection with human rhinovirus type 2 (HRV-2) has been measured both by neutralization and by ELISA. Six volunteers who had HRV-2-specific antibodies in either serum or nasal secretions before HRV-2 inoculation were resistant to infection and illness. Of the remaining 11 volunteers who had little pre-existing HRV-2-specific antibody, one was immune but 10 became infected and displayed increases in HRV-2-specific antibodies. These antibodies first increased 1–2 weeks after infection and reached a maximum at 5 weeks. All six resistant volunteers who had high pre-existing antibody and eight of the volunteers who became infected maintained their HRV-2-specific antibody for at least 1 year. At this time they were protected against reinfection. Two volunteers showed decreases in HRV-2-specific antibodies from either serum or nasal secretions. They became infected but not ill after HRV-2 inoculation 1 year later. |
| Databáze: | OpenAIRE |
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