Effects of a nitric oxide synthase Type II inhibitor on compound action potential thresholds in experimental endolymphatic hydrops
| Autor: | Cláudio Márcio Yudi Ikino, Karina Midori Sato, Newton Macuco Capella, Roseli Saraiva Moreira Bittar |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Guinea Pigs Action Potentials Nitric Oxide Synthase Type II Guanidines Nitric oxide chemistry.chemical_compound Random Allocation Animal model Internal medicine medicine Animals Endolymphatic Hydrops Endolymphatic hydrops Cochlea Random allocation business.industry Electrocochleography medicine.disease Sensory Systems Compound muscle action potential Audiometry Evoked Response Endocrinology Otorhinolaryngology chemistry Female Neurology (clinical) business |
| Zdroj: | Otologyneurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 28(1) |
| ISSN: | 1531-7129 |
| Popis: | Nitric oxide (NO) is likely to be synthesized by nitric oxide synthase Type II (NOS II) action and may partake in the origin of changes of compound action potential (CAP) threshold observed in guinea pigs with induced endolymphatic hydrops. This study aimed to assess the action of a NOS II inhibitor on CAP thresholds in these experimental samples.In guinea pigs with experimental endolymphatic hydrops, there are lesions on the cochlea and progressive increase of CAP threshold. NOS II was found in the cochlea of this animal model, and it was inferred that NO can contribute by such alterations.The animals were divided into two groups, in which eight received an intake of a NOS II inhibitor, aminoguanidine, and another eight served as a control group. During 16 weeks, CAP thresholds at 1,000, 2,000, 4,000 and 6,000 on electrocochleography were compared between the groups.The group that had an intake of aminoguanidine showed a lower increase on CAP thresholds at 2,000 (p0.05) and 6,000 Hz (p0.05) at the 12th postoperative week, and at 1,000 (p0.05), 2,000 (p0.001), 4,000 (p0.001),and 6,000 Hz (p0.001) at the 16th week.We conclude that NOS II inhibitor reduced the elevation of CAP thresholds in experimentally induced endolymphatic hydrops. |
| Databáze: | OpenAIRE |
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