Cyclopeptide Alkaloids from Ziziphus apetala
| Autor: | Ning-Hua Tan, Chang-Jiu Ji, Wen-Jun He, Yu Shen, Ying Leng, Jing Han, Jun-Ting Fan, Wenyan Xu, Ling-Dong Kong, Guang-Zhi Zeng |
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| Rok vydání: | 2011 |
| Předmět: |
endocrine system
Stereochemistry Pharmaceutical Science Dehydrogenase Biology Peptides Cyclic Ziziphus apetala Analytical Chemistry Inhibitory Concentration 50 Mice Alkaloids Drug Discovery Ic50 values Animals Humans Inhibitory concentration 50 Enzyme Inhibitors Cytotoxicity Pharmacology Traditional medicine Organic Chemistry Ziziphus Antidepressive Agents In vitro Complementary and alternative medicine Molecular Medicine 11-beta-Hydroxysteroid Dehydrogenases Female |
| Zdroj: | Journal of Natural Products. 74:2571-2575 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np200755t |
| Popis: | Six novel Ia₃-type cyclopeptide alkaloids (1-6) were isolated from stems of Ziziphus apetala. Compound 5 and the known compounds mauritine A (7) and mauritine F (8) were isolated from the roots. Their structures were determined by spectroscopic analyses and chemical methods. The total alkaloids from the roots and the isolated cyclopeptide alkaloids were tested for antidepressant behavior on mice, cytotoxicity, and 11β-hydroxysteroid dehydrogenase (11β-HSD) inhibition in vitro. Only mauritine A (7) showed inhibitory activity on 11β-HSD1, with IC₅₀ values of 52.0 (human) and 31.2 μg/mL (mouse). |
| Databáze: | OpenAIRE |
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