Myocardial perfusion imaging with 99 mTc - tetrofosmin SPECT in breast cancer patients that received postoperative radiotherapy: a case-control study

Autor: Antonio Capizzello, Vasilios Ragos, Nikolaos Fotou, Chrissa Sioka, Andreas Fotopoulos, Periklis Tsekeris, Ifigenia Tasiou, Eftychia Tzima, Thomas Exarchopoulos
Jazyk: angličtina
Předmět:
lcsh:Medical physics. Medical radiology. Nuclear medicine
Adult
medicine.medical_specialty
lcsh:R895-920
medicine.medical_treatment
Postoperative radiotherapy
Breast Neoplasms
lcsh:RC254-282
Single photon emission
Myocardial perfusion imaging
Breast cancer
Organophosphorus Compounds
Risk Factors
Cardiac toxicity
medicine
Humans
Radiology
Nuclear Medicine and imaging
Postoperative Period
Aged
Aged
80 and over
Tomography
Emission-Computed
Single-Photon
Radiotherapy
medicine.diagnostic_test
business.industry
Research
Myocardium
Case-control study
Organotechnetium Compounds
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Radiation therapy
Treatment Outcome
Oncology
Chemotherapy
Adjuvant
Radiology Nuclear Medicine and imaging
SPECT
Case-Control Studies
Female
Radiology
Radiopharmaceuticals
Nuclear medicine
business
Zdroj: Radiation Oncology (London, England)
Radiation Oncology, Vol 6, Iss 1, p 151 (2011)
ISSN: 1748-717X
DOI: 10.1186/1748-717x-6-151
Popis: Purpose To evaluate the cardiac toxicity of radiotherapy (RT) in breast cancer (BC) patients employing myocardial perfusion imaging (MPI) with Tc-99 m Tetrofosmin - single photon emission computer tomography (T-SPECT). Materials and methods We studied 46 BC female patients (28 patients with left and 18 patients with right BC) treated with postoperative RT compared to a control group of 85 age-matched females. The median time of RT to SPECT was 40 months (6-263). Results Abnormalities in the summed stress score (SSS) were found in 54% of left BC patients, 44.4% of right BC patients, and 32.9% of controls. In left BC patients there were significantly more SSS abnormalities compared to controls (4.0 ± 3.5 vs 2.6 ± 2.0, p = 0.05) and possible trend of increased abnormalities of right BC patients (3.7 ± 3.0 vs 2.6 ± 2.0, p = 0.14). Multiple regression analysis showed more abnormalities in the MPI of left BC patients compared to controls (SSS, p = 0.0001); Marginal toxicity was also noted in right BC patients (SSS, p = 0.045). No additional toxicity was found in patients that received adjuvant cardiotoxic chemotherapy. All T-SPECT abnormalities were clinically silent. Conclusion The study suggests that radiation therapy to BC patients result in MPI abnormalities but without apparent clinical consequences.
Databáze: OpenAIRE
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