Antimicrobial susceptibility and MIC distribution of 41 drugs against clinical isolates from China and reference strains of nontuberculous mycobacteria
| Autor: | Yanhong Tan, Haican Liu, Li-li Zhao, Hui Pang, Zhiguang Liu, Guilian Li, Ming-Xiang Huang, Yi Jiang, Chao Li, Donglei Xu, Yuanzhi Xia, Jian-Hao Wei, Kanglin Wan, Qian Guo, Xiuqin Zhao |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microbiology (medical) China Rifabutin Capreomycin 030106 microbiology Mycobacterium Infections Nontuberculous Tigecycline Microbial Sensitivity Tests Meropenem Microbiology 03 medical and health sciences Minimum inhibitory concentration chemistry.chemical_compound 0302 clinical medicine polycyclic compounds medicine Humans Pharmacology (medical) 030212 general & internal medicine biology Nontuberculous Mycobacteria General Medicine bacterial infections and mycoses Antimicrobial biology.organism_classification Anti-Bacterial Agents Infectious Diseases chemistry Linezolid Nontuberculous mycobacteria medicine.drug |
| Zdroj: | International journal of antimicrobial agents. 49(3) |
| ISSN: | 1872-7913 |
| Popis: | To treat nontuberculous mycobacteria (NTM) infections more optimally, further research pertaining to mycobacterial susceptibility to antimicrobial agents is required. A total of 82 species of NTM reference strains and 23 species of NTM clinical isolates were included. Minimum inhibitory concentrations (MICs) for 41 drugs were determined using the microdilution method in cation-adjusted Mueller-Hinton broth. The results showed that most of the NTM were susceptible to aminoglycosides, quinolones, three macrolides (clarithromycin, azithromycin and roxithromycin), cefmetazole, linezolid and capreomycin. Rapidly growing mycobacterium strains were additionally susceptible to cefoxitin, clofazimine, rifapentine, doxycycline, minocycline, tigecycline, meropenem and sulfamethoxazole, whereas slowly growing mycobacterium strains were additionally susceptible to rifabutin. This study on the susceptibility of NTM includes the largest sample size of Chinese clinical isolates and reference strains. NTM species-specific drug susceptibility patterns suggested that it is urgent to identify the species of NTM, to normalise the treatment of NTM infectious disease and to clarify the resistance mechanisms of NTM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect