Association of Serum Neurofilament Light Levels With Long-term Brain Atrophy in Patients With a First Multiple Sclerosis Episode
| Autor: | Revere P. Kinkel, Richard A. Rudick, Ray Su, Bob Engle, Carol Singh, Alfred Sandrock, Bernd C. Kieseier, Tatiana Plavina, Dipen Sangurdekar, Suzanne Szak, Carl de Moor, Elizabeth Fisher, Arie R Gafson, Jaya Goyal |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Multiple Sclerosis Time Factors Gastroenterology Cohort Studies Atrophy Neurofilament Proteins Predictive Value of Tests Internal medicine Severity of illness medicine Humans Original Investigation Cerebral atrophy Clinically isolated syndrome Expanded Disability Status Scale business.industry Multiple sclerosis Brain General Medicine medicine.disease Prognosis Magnetic Resonance Imaging Biomarker (medicine) Female business Biomarkers Cohort study |
| Zdroj: | JAMA Netw Open |
| ISSN: | 2574-3805 |
| Popis: | IMPORTANCE: Data are needed on the potential long-term prognostic association of serum neurofilament light in multiple sclerosis (MS). OBJECTIVE: To evaluate serum neurofilament light as a biomarker associated with long-term disease outcomes in clinically isolated syndrome. DESIGN, SETTING, AND PARTICIPANTS: This post hoc cohort study used data from the Controlled High-Risk Avonex Multiple Sclerosis Prevention Study, a 36-month, multicenter, placebo-controlled interferon β-1a randomized clinical trial conducted from April 1996 to March 2000, and its long-term (5- and 10-year) extension study from February 2001 to March 2009. Participants included individuals with a symptomatic initial demyelinating event and brain magnetic resonance imaging (MRI) lesions suggestive of MS. Data were analyzed from April 2017 through 2019. EXPOSURE: The variable of interest was naturally occurring serum neurofilament light concentration MAIN OUTCOMES AND MEASURES: Gadolinium-enhancing (Gd(+)) lesion number, T2 lesion volume, and brain parenchymal fraction, a measure of brain atrophy were measured at baseline and 5 and 10 years. Multivariate regression models evaluated whether age, sex, and baseline covariates, including serum neurofilament light, brain parenchymal fraction, Expanded Disability Status Scale, Gd(+) lesion count, and T2 lesion volume, were associated with brain parenchymal fraction changes over 5 and 10 years. RESULTS: Among 308 included participants (mean [SD] age, 33.2 [7.6] years; 234 [76.0%] women), baseline serum neurofilament light concentrations were associated with Gd(+) lesions (Spearman r = 0.41; P |
| Databáze: | OpenAIRE |
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