Tumor DNA content as a prognostic indicator in squamous cell carcinoma of the head and neck region
| Autor: | Khalil Sheibani, Lawrence D. Wagman, J. David Beatty, Daniel U. Riihimaki, Irene W. Zak, Robert L. Gardine, William A. Kokal, Jose J. Terz |
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| Rok vydání: | 1988 |
| Předmět: |
Male
Larynx Pathology medicine.medical_specialty Flow cytometry chemistry.chemical_compound Humans Medicine Neoplasm Invasiveness Head and neck Laryngeal Neoplasms Aged Mouth neoplasm medicine.diagnostic_test business.industry Pharynx Pharyngeal Neoplasms DNA Neoplasm General Medicine Middle Aged Laryngeal Neoplasm Flow Cytometry Prognosis stomatognathic diseases Pharyngeal Neoplasm medicine.anatomical_structure chemistry Head and Neck Neoplasms Carcinoma Squamous Cell Female Mouth Neoplasms Surgery business DNA |
| Zdroj: | The American Journal of Surgery. 156:276-280 |
| ISSN: | 0002-9610 |
| DOI: | 10.1016/s0002-9610(88)80291-5 |
| Popis: | Our purpose in this study was to determine whether tumor DNA content is a prognostic factor independent of other standard clinical and histologic parameters in squamous cell carcinoma (SCC) of the head and neck region. Tumor DNA content was determined in 76 patients with primary resectable SCC of the oral cavity, larynx, or pharynx who were treated from 1978 to 1984 at the City of Hope. In addition, we measured various clinical and pathologic parameters in all patients. In comparison to patients with diploid SCC, those with aneuploid SCC had significantly decreased relapse-free and overall survival rates (p less than 0.001 for both). A Cox regression analysis demonstrated that tumor DNA content was a prognostic factor independent of all clinicopathologic features examined. By regression analysis, it was the single most important prognostic factor in determining relapse and death from SCC (p less than 0.001 for both). |
| Databáze: | OpenAIRE |
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