Ferromagnetic hyperthermia: Functional and histopathologic effects on normal rabbit ocular tissue
| Autor: | G. Bresnick, Laura Gentry, Richard A. Steeves, Timothy G. Murray, H. C. Boldt, William F. Mieler, Dean T. Tompkins |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Uveal Neoplasms
Hyperthermia Cancer Research Pathology medicine.medical_specialty genetic structures Thermometers Physiology Eye disease Ocular Melanoma Melanoma Experimental Eye Ferric Compounds chemistry.chemical_compound Eye Injuries Physiology (medical) Ophthalmology Electroretinography medicine Animals Lagomorpha medicine.diagnostic_test biology business.industry Temperature Fundus photography Retinal Hyperthermia Induced medicine.disease biology.organism_classification eye diseases chemistry Evaluation Studies as Topic Histopathology Rabbits sense organs business |
| Zdroj: | International Journal of Hyperthermia. 13:423-436 |
| ISSN: | 1464-5157 0265-6736 |
| Popis: | Ferromagnetic (FM) hyperthermia has previously been evaluated in a rabbit tumour model of ocular melanoma. To study the effect of focal heating in normal rabbit eyes, FM seeds were implanted into a 14-mm episcleral plaque an heated to operating temperatures of 48 or 58 degrees C. Thermal induction was performed by placing rabbits in a uniform, oscillating (11 kHz) magnetic field operating at 1200 W and as H-field strength of 265 A/m. Eyes were heated for 60 min with continuous scleral temperature monitoring. Hyperthermic effects were monitored by direct opthalmic examination, fundus photography, serial electroretinography and histopathology. Intraocular temperatures were mapped with direct fiberoptic thermometry. All treatment effects were confined to the area covered by the episcleral plaque. Direct ophthalmoscopic examination revealed early retinal whitening during heat induction followed by localized exudative retinal detachments, limited to the area of the retinal surface overlying the plaque, that resolved spontaneously. Serial electroretinography was virtually indistinguishable between the 48 and 54 degrees C temperature groups. We noted a minimal alteration in a- and b-wave amplitudes with no changes in implicit times. Histopathology at 3 weeks post-treatment documented chorioretinal scarring overlying the thermal plaque treatment zone. No evidence of heamorrhage infection, cataract or scleral thinning was noted. This study documents the apparent focal containment of thermal effects with FM heating utilizing operating temperatures ad high as 54 degrees C for 60 min, and discloses no evidence of diffuse ocular toxicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|