Determination of zinc (II) in pharmaceuticals based on a flow-through bulk optode
| Autor: | M.I. Albero, Rosario Expósito, J. Ortuño, Concepción Sánchez-Pedreño, M.S. García |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Detection limit
Flow injection analysis Optics and Photonics Calibration curve Clinical Biochemistry Analytical chemistry Pharmaceutical Science chemistry.chemical_element Zinc Vinyl chloride Analytical Chemistry chemistry.chemical_compound Membrane Pharmaceutical Preparations chemistry Flow Injection Analysis Drug Discovery Cellulose Optode Spectroscopy |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 29:779-786 |
| ISSN: | 0731-7085 |
| DOI: | 10.1016/s0731-7085(02)00173-5 |
| Popis: | A method based on flow injection (FI), was applied for the determination of Zn (II) using a flow-through bulk optode membrane that incorporates 1-(2-pyridylazo)-2-naphthol in a plasticized poly (vinyl chloride) membrane entrapped in a cellulose support. The calibration graph plotting the reflectance at 562 nm versus [Zn (II)] was linear in the range 0.16-3.27 mgl(-1) (2.5 x 10(-6)-5 x 10(-5) M) with a detection limit of 0.10 mgl(-1). The variation coefficients of the sensor response for 0.33 mgl(-1) of Zn (II) were +/-0.11% for consecutive measurements (n=10), +/-0.19% between days (n=5) and +/-0.22% between different membranes (n=6). The sensor can be readily regenerated with the same acetic/acetate carrier of pH 3.9. The FI method proposed was applied to the determination of zinc (II) in pharmaceuticals. |
| Databáze: | OpenAIRE |
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