Exposure to bisphenol A in young adult mice does not alter ovulation but does alter the fertilization ability of oocytes
| Autor: | Teresita Rocio Moore-Ambriz, Brenda Ramos-Robles, Mineko Shibayama, Ramsés Santacruz-Márquez, Manuel Sánchez-Gutiérrez, Belem Piña-Guzmán, Deyanira Guadalupe Acuña-Hernández, Adolfo Sierra-Santoyo, Isabel Hernández-Ochoa |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Ovulation endocrine system medicine.medical_specialty Zygote media_common.quotation_subject medicine.medical_treatment Estrous Cycle Biology Toxicology Mice Human fertilization Ovarian Follicle Phenols Internal medicine medicine Animals Benzhydryl Compounds Ovarian follicle media_common Pharmacology Estrous cycle In vitro fertilisation urogenital system Oocyte Mice Inbred C57BL medicine.anatomical_structure Endocrinology Fertilization Oocytes Female Folliculogenesis hormones hormone substitutes and hormone antagonists |
| Zdroj: | Toxicology and Applied Pharmacology. 289:507-514 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/j.taap.2015.10.010 |
| Popis: | Follicle growth culminates in ovulation, which allows for the expulsion of fertilizable oocytes and the formation of corpora lutea. Bisphenol A (BPA) is present in many consumer products, and it has been suggested that BPA impairs ovulation; however, the underlying mechanisms are unknown. Therefore, this study first evaluated whether BPA alters ovulation by affecting folliculogenesis, the number of corpora lutea or eggs shed to the oviduct, ovarian gonadotropin responsiveness, hormone levels, and estrous cyclicity. Because it has been suggested (but not directly confirmed) that BPA exerts toxic effects on the fertilization ability of oocytes, a second aim was to evaluate whether BPA impacts the oocyte fertilization rate using an in vitro fertilization assay and mating. The possible effects on early zygote development were also examined. Young adult female C57BL/6J mice (39 days old) were orally dosed with corn oil (vehicle) or 50 μg/kgbw/day BPA for a period encompassing the first three reproductive cycles (12-15 days). BPA exposure did not alter any parameters related to ovulation. Moreover, BPA exposure reduced the percentage of fertilized oocytes after either in vitro fertilization or mating, but it did not alter the zygotic stages. The data indicate that exposure to the reference dose of BPA does not impact ovulation but that it does influence the oocyte quality in terms of its fertilization ability. |
| Databáze: | OpenAIRE |
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