Effect of wheat germ on metabolic markers: a systematic review and meta-analysis of randomized controlled trials
| Autor: | Eunseon Jeong, Ji Yeon Kim, Humna Liaqat, Kyeong Jin Kim |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
030309 nutrition & dietetics Applied Microbiology and Biotechnology Article Mean difference law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial law Internal medicine Total cholesterol Medicine 030212 general & internal medicine Triglycerides 0303 health sciences business.industry Cholesterol Wheat germ Confidence interval Metabolic markers Glucose chemistry Meta-analysis business Food Science Biotechnology |
| Zdroj: | Food Science and Biotechnology |
| ISSN: | 2092-6456 1226-7708 |
| DOI: | 10.1007/s10068-020-00769-9 |
| Popis: | This systematic review and meta-analysis aim to evaluate the association of wheat germ interventions and metabolic markers. An electronic search was performed by mid-May 2019 in the PubMed, Google Scholar, and Web of Science databases. Quality was evaluated using the risk of bias assessment tools. Thirty-three randomized controlled trials (RCTs) were identified, among which ten were suitable and systematically reviewed based on biomarkers (cholesterol, triglycerides, glucose, and oxidative stress). Three biomarkers in five eligible studies were investigated by meta-analysis. Total cholesterol showed non-significant results (p = 0.98), with standard mean difference (SMD) of − 0.01 (95% confidence interval; − 0.17, 0.16). The SMD was − 0.06 (95% CI − 0.41, 0.29, n = 4) for triglycerides and − 0.09 (95% CI − 0.62, 0.45, n = 2) for glucose. No biomarkers showed heterogeneity (0%). This review revealed non-significant association between wheat germ interventions and metabolic markers. Sensitive analysis with high-quality RCTs may be worth trying. |
| Databáze: | OpenAIRE |
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