Association of single nucleotide polymorphism in CD28(C/T-I3 + 17) and CD40 (C/T-1) genes with the Graves disease
| Autor: | Hira Fatima, Furhan Iqbal, Atif Akbar, Saima Mustafa, Sadia Fatima, Tafheem Khosa, Rehan S. Shaikh |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Graves' disease Single-nucleotide polymorphism Disease Polymorphism Single Nucleotide Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine CD28 Antigens Risk Factors Internal medicine Genotype Humans Medicine Genetic Predisposition to Disease Pakistan 030212 general & internal medicine CD40 Antigens Child CD40 Molecular epidemiology Cluster of differentiation biology business.industry Thyroid General Medicine Middle Aged medicine.disease Graves Disease medicine.anatomical_structure Case-Control Studies 030220 oncology & carcinogenesis biology.protein business |
| Zdroj: | Journal of the Pakistan Medical Association. :1 |
| ISSN: | 0030-9982 |
| DOI: | 10.5455/jpma.259380 |
| Popis: | OBJECTIVE To find out a correlation between the single nucleotide polymorphisms in cluster of differentiation 28 and cluster of differentiation 40 genes with Graves' disease, if any. METHODS This case-control study was conducted at the Multan Institute of Nuclear Medicine and Radiotherapy, Multan, Pakistan, and comprised blood samples of Graves' disease patients and controls. Various risk factors were also correlated either with the genotype at each single-nucleotide polymorphism or with various combinations of genotypes studied during present investigation. RESULTS Of the 160 samples, there were 80(50%) each from patients and controls. Risk factor analysis revealed that gender (p=0.008), marital status (p |
| Databáze: | OpenAIRE |
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