A Novel Folate-Targeted Nanoliposomal System of Doxorubicin for Cancer Targeting
| Autor: | AA Lohade, Krishna R. Iyer, Rajesh R Jain, Sushant Roy, Mala D Menon, Yogita Pawar, M.G.R. Rajan, Hemant H Shimpi |
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| Rok vydání: | 2015 |
| Předmět: |
Biodistribution
Pharmaceutical Science Antineoplastic Agents 02 engineering and technology Aquatic Science Pharmacology Ligands 03 medical and health sciences Mice 0302 clinical medicine Drug Delivery Systems Folic Acid Cell Line Tumor Neoplasms Drug Discovery medicine Animals Humans Doxorubicin Tissue Distribution Cytotoxicity Ecology Evolution Behavior and Systematics chemistry.chemical_classification Liposome Ecology Cancer General Medicine 021001 nanoscience & nanotechnology medicine.disease Mice Inbred C57BL Cholesterol chemistry Targeted drug delivery Transferrin A549 Cells 030220 oncology & carcinogenesis Drug delivery Liposomes Nanoparticles Female 0210 nano-technology Agronomy and Crop Science medicine.drug |
| Zdroj: | AAPS PharmSciTech. 17(6) |
| ISSN: | 1530-9932 |
| Popis: | Targeted drug delivery systems for cancer improves anti-tumor efficacy and reduces systemic toxicity by restricting availability of cytotoxic drugs within tumors. Targeting moieties, such as natural ligands (folic acid, transferrin, and biotin) which are overexpressed on tumors, have been used to enhance liposome-encapsulated drug accumulation within tumors and resulted in better control. In this report, we explored the scope of targeting ligand folic acid, which is incorporated in liposome systems using folic acid-modified cholesterol (CPF), enabled highly selective tumor-targeted delivery of liposome-encapsulated doxorubicin and resulted in increased cytotoxicity within tumors. Folate-tagged poloxamer-coated liposomes (FDL) were found to have significantly higher cellular uptake than conventional poloxamer-coated liposomes (DL), as confirmed by fluorometric analysis in B16F10 melanoma cells. Biodistribution study of the radiolabeled liposomal system indicated the significantly higher tumor uptake of FDL as compared to DL. Anti-tumor activity of FDL against murine B16F10 melanoma tumor-bearing mice revealed that FDL inhibited tumor growth more efficiently than the DL. Taken together, the results demonstrated the significant potential of the folate-conjugated nanoliposomal system for drug delivery to tumors. |
| Databáze: | OpenAIRE |
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