Differential expression of enhancer of zeste homolog 2 (EZH2) protein in small cell and aggressive B-cell non-Hodgkin lymphomas and differential regulation of EZH2 expression by p-ERK1/2 and MYC in aggressive B-cell lymphomas

Autor:	Ashley Pelton, David M. Dorfman, Xuejun Tian, Ali Shahsafaei
Rok vydání:	2016
Předmět:	0301 basic medicine Pathology medicine.medical_specialty Cell signaling Lymphoma B-Cell Cell macromolecular substances Biology Pathology and Forensic Medicine Proto-Oncogene Proteins c-myc 03 medical and health sciences 0302 clinical medicine immune system diseases hemic and lymphatic diseases Biomarkers Tumor medicine Humans Enhancer of Zeste Homolog 2 Protein Phosphorylation B cell Cell Proliferation Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 EZH2 medicine.disease Immunohistochemistry Leukemia Lymphocytic Chronic B-Cell BCL10 Lymphoma 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer research Signal transduction REL Signal Transduction
Zdroj:	Modern Pathology. 29:1050-1057
ISSN:	0893-3952
DOI:	10.1038/modpathol.2016.114
Popis:	EZH2, a member of the polycomb protein group, is an important methyltransferase that is overexpressed in various neoplasms. We found that in small cell B-cell lymphomas, EZH2 is expressed in
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e32738175ae798d303ca8d6c3ed921 https://doi.org/10.1038/modpathol.2016.114 Zobrazit plný text záznamu Full text from SpringerLink