Effects of Terminal Sterilization on PEG-Based Bioresorbable Polymers Used in Biomedical Applications
| Autor: | Kenneth Aston, Meiyu Mao, Joachim Kohn, Vinod B. Damodaran, Kurt Pricer, N. Sanjeeva Murthy, Frederick Halperin, Divya Bhatnagar, Ganesan Subramanian, Koustubh S. Dube |
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| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Materials science Polymers and Plastics Ethylene oxide General Chemical Engineering Carboxylic acid 0206 medical engineering Organic Chemistry technology industry and agriculture Ether Terminal Sterilization 02 engineering and technology Polymer Sterilization (microbiology) 021001 nanoscience & nanotechnology 020601 biomedical engineering Article chemistry.chemical_compound chemistry Polymer chemistry PEG ratio Materials Chemistry 0210 nano-technology Ethylene glycol |
| Zdroj: | Macromolecular Materials and Engineering. 301:1211-1224 |
| ISSN: | 1438-7492 |
| Popis: | The effects of ethylene oxide (EO), vaporized hydrogen peroxide (VHP), gamma (γ) radiation, and electron-beam (E-beam) on the physiochemical and morphological properties of medical device polymers are investigated. Polymers with ether, carbonate, carboxylic acid, amide and ester functionalities are selected from a family of poly(ethylene glycol) (PEG) containing tyrosine-derived polycarbonates (TyrPCs) to include slow, medium, fast, and ultra-fast degrading polymers. Poly(lactic acid) (PLA) is used for comparison. Molecular weight (Mw) of all tested polymers decreases upon gamma and E-beam, and this effect becomes more pronounced at higher PEG content. Gamma sterilization increases the glass transition temperature of polymers with high PEG content. EO esterifies the carboxylic acid groups in desaminotyrosol-tyrosine (DT) and causes significant degradation. VHP causes hydroxylation of the phenyl ring, and hydrolytic degradation. This study signifies the importance of the chemical composition when selecting a sterilization method, and provides suggested conditions for each of the sterilization methods. |
| Databáze: | OpenAIRE |
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