Dosimetric analysis of Deep Inspiratory Breath-hold technique (DIBH) in left-sided breast cancer radiotherapy and evaluation of pre-treatment predictors of cardiac doses for guiding patient selection for DIBH

Autor:	Kazi Sazzad Manir, Bipasha Pal, Soura Palit, Jyotirup Goswami, Soujanya Ferdinand, Monidipa Mondal, Sayan Das, Suresh Das, Suman Mallik, Papai Sarkar, Arijit Sen, Subhayan Mondal
Rok vydání:	2021
Předmět:	HH Heart Height HCWD Heart Chest Wall Distance LAD Left Anterior Descending medicine.medical_treatment LOD Lung Orthogonal Distance SCF Supraclavicular Fossa CLD Central Lung Distance 030218 nuclear medicine & medical imaging HV Heart Volume Breast cancer 0302 clinical medicine CS Chest Separation OAR Organs-at-risk Medicine Lung volumes MHD Maximum Heart Depth integumentary system PTV Planning target volume Oncology (nursing) Health Policy RTOG Radiation Therapy Oncology Group HCWL Heart Chest Wall Length ROC Receiver Operating Characteristic CCD Cardiac Contact Distance lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.anatomical_structure EORTC European Organization for Research and Treatment of Cancer 030220 oncology & carcinogenesis Radiology Research Article lcsh:Medical physics. Medical radiology. Nuclear medicine medicine.medical_specialty HVIF Heart Volume in Field NTCP Normal Tissue Complications Probability lcsh:R895-920 RPM Real-time Position Management Modified Radical Mastectomy LV Lung Volume Breast cancer radiotherapy Deep inspiratory breath-hold lcsh:RC254-282 Left sided 03 medical and health sciences MRM Modified Radical Mastectomy DVH Dose Volume Histograms Radiology Nuclear Medicine and imaging Care Planning DIBH Deep Inspiratory Breath-hold CT Computer Tomography Radiotherapy Receiver operating characteristic RNI Regional Nodal Irradiation business.industry 3DCRT Three-Dimensional Conformal Radiation Therapy ABC™ Active Breathing Coordinator™ AUC Area under the curve medicine.disease Radiation therapy CD Chest Depth FB Free Breathing IMC Internal Mammary Chain BCS Breast Conservation Surgery BMI Body Mass Index business Supraclavicular fossa Dosimetric predictors
Zdroj:	Technical Innovations & Patient Support in Radiation Oncology, Vol 17, Iss, Pp 25-31 (2021) Technical Innovations & Patient Support in Radiation Oncology
ISSN:	2405-6324
DOI:	10.1016/j.tipsro.2021.02.006
Popis:	Highlights • DIBH results in cardiac sparing in left sided breast cancer radiotherapy. • Heart volume in field and maximum heart distance are predictors of cardiac sparing. • Thresholds of these anatomical predictors can help to select patients for DIBH. Introduction The risk of radiotherapy-associated cardiovascular disease has been a concern for decades in breast cancer survivors. The objective of our study is to evaluate the dosimetric benefit of Deep Inspiratory Breath-hold technique (DIBH) on organs-at-risk (OAR) sparing in left-sided breast cancer radiotherapy and to find out pre-treatment predictors of cardiac doses for guiding patient selection for DIBH. Material and methods Pre-radiotherapy planning CT scans were done in Free Breathing (FB) and in DIBH [using Active Breathing Coordinator system (ABC™)] in 31 left sided breast cancer patients. 3DCRT plans were generated for both scans. Comparison of anatomical and dosimetric variables were done using paired t test and correlation was evaluated using Pearson correlation. Linear regression was used to get independent predictors of cardiac sparing and Receiver Operating Characteristic (ROC) curve analysis was done to find out the specific threshold of the predictors. Results There was a 39.15% reduction in mean heart dose in DIBH compared to FB (2.4 Gy vs 4.01 Gy) (p
Databáze:	OpenAIRE
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