Unique spectral signature of human cutaneous squamous cell carcinoma by photoacoustic imaging
| Autor: | Rafi Sheikh, Malin Malmsjö, Rehan Chakari, Bertil Persson, Magnus Cinthio, Karin Wickerström, John Albinsson, Bodil Gesslein, Ulf Dahlstrand, Jenny Hult, Tobias Erlöv, Aboma Merdasa |
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| Rok vydání: | 2020 |
| Předmět: |
Skin Neoplasms
Cutaneous squamous cell carcinoma Materials science General Physics and Astronomy Photoacoustic imaging in biomedicine 01 natural sciences General Biochemistry Genetics and Molecular Biology Photoacoustic Techniques 010309 optics 0103 physical sciences Carcinoma medicine Humans General Materials Science Skin Ultrasonography Spectral signature business.industry 010401 analytical chemistry Ultrasound General Engineering General Chemistry medicine.disease 0104 chemical sciences Carcinoma Squamous Cell Imaging technology Skin cancer business Biomedical engineering |
| Zdroj: | Journal of Biophotonics. 13 |
| ISSN: | 1864-0648 1864-063X |
| Popis: | Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer with metastatic potential. To reduce reoperations due to nonradical excision, there is a need to develop a technique for identification of tumor margins preoperatively. Photoacoustic (PA) imaging is a novel imaging technology that combines the strengths of laser optics and ultrasound. Our aim was to determine the spectral signature of cSCC using PA imaging and to use this signature to visualize tumor architecture and borders. Two-dimensional PA images of 33 cSCCs and surrounding healthy skin were acquired ex vivo, using 59 excitation wavelengths from 680 to 970 nm. The spectral response of the cSCCs was compared to healthy tissue, and the difference was found to be greatest at wavelengths in the range 765 to 960 nm (P |
| Databáze: | OpenAIRE |
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