Pulsed radiation therapy to improve systemic control of metastatic cancer
| Autor: | Maria Angelica Cortez, Ethan Y Hsu, Meidi Gu, Chike O. Abana, Kewen He, Vivek Verma, Dawei Chen, James W. Welsh, Nahum Puebla-Osorio, Roshal R. Patel, Hampartsoum B. Barsoumian, Duygu Sezen |
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| Přispěvatelé: | Sezen, Duygu (ORCID 0000-0002-4505-2280 & YÖK ID 170535), He, Kewen, Barsoumian, Hampartsoum B., Puebla-Osorio, Nahum, Hsu, Ethan Y., Verma, Vivek, Abana, Chike O., Chen, Dawei, Patel, Roshal R., Gu, Meidi, Cortez, Maria Angelica, Welsh, James W., School of Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pulsed radiation
Systemic disease Cancer Research business.industry medicine.medical_treatment Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cancer adaptive immunity Immunotherapy Disease memory effect medicine.disease Acquired immune system radiation therapy Radiation therapy metastatic cancer Antigen Oncology Perspective medicine Cancer research immunotherapy business Metastatic cancer Adaptive immunity Memory effect RC254-282 |
| Zdroj: | Frontiers in Oncology Frontiers in Oncology, Vol 11 (2021) |
| Popis: | Radiation therapy (RT) is emerging as an interventional modality in the cancer-immunity cycle, augmenting the activation of an adaptive immune response against tumors. RT, particularly in combination with immunotherapy, can enhance immune memory effects and shape the tumor-directed T-cell populations. However, a single cycle of RT delivered to a limited number of polymetastatic lesions is rarely sufficient to achieve systemic control. We hypothesize that several rounds of RT, akin to several rounds of immunotherapeutic drugs, is likely to provide greater clinical benefit to patients with metastatic disease. We propose that the repeated exposure to tumor antigens released by ""pulsed-RT"" (i.e., treating 2-4 tumor lesions with 3 irradiation cycles given one month apart) may amplify the adaptive immune response by expanding the tumor-specific T-cell receptor repertoire, the production of high-affinity tumor antibodies, and the generation of memory lymphocytes and thereby improve immune control of systemic disease. National Cancer Institute; National Institutes of Health; Cancer Center Support (Core) Grant |
| Databáze: | OpenAIRE |
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