Ventral Intermediate Nucleus Versus Zona Incerta Region Deep Brain Stimulation in Essential Tremor
| Autor: | Juan C. Giugni, Adolfo Ramirez-Zamora, Justin D. Hilliard, Daniel Martinez-Ramirez, Bilal Ahmed, Jackson N. Cagle, Joshua K. Wong, Erin H. Monari, Leonardo Almeida, Christopher W. Hess, Robert S. Eisinger, Kelly D. Foote, Aysegul Gunduz, Alberto R. Bona, Aparna Wagle Shukla, Michael S. Okun |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Deep brain stimulation medicine.medical_treatment Stimulation Audiology behavioral disciplines and activities law.invention 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Randomized controlled trial Rating scale law medicine Neurostimulation Research Articles Essential tremor medicine.disease nervous system diseases surgical procedures operative 030104 developmental biology medicine.anatomical_structure nervous system Neurology Zona incerta Neurology (clinical) Analysis of variance Psychology therapeutics 030217 neurology & neurosurgery |
| Zdroj: | Movement disorders clinical practice. 5(1) |
| ISSN: | 2330-1619 |
| Popis: | Background The ventral intermediate nucleus (VIM) is the target of choice for Essential Tremor (ET) deep brain stimulation (DBS). Renewed interest in caudal zona incerta (cZI) stimulation for tremor control has recently emerged and some groups believe this approach may address long-term reduction of benefit seen with VIM-DBS. Objectives To compare clinical outcomes and DBS programming in the long-term between VIM and cZI neurostimulation in ET-DBS patients. Materials and Methods A retrospective review of 53 DBS leads from 47 patients was performed. Patients were classified into VIM or cZI groups according to the location of the activated DBS contact. Demographics, DBS settings, and Tremor Rating Scale scores were compared between groups at baseline and yearly follow-up to 4 years after DBS. Student t-tests and ANOVA were used to compare variables between groups. Results Relative to baseline, an improvement in ON-DBS tremor scores was observed in both groups from 6 months to 4 years post-DBS (p |
| Databáze: | OpenAIRE |
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