5-HT1AReceptor Activation before Acute Stress Counteracted the Induced Long-Term Behavioral Effects
| Autor: | José Rioja, Alicia Doña, Salvador González-Barón, M García, M I Cuadrado, Luis J. Santín, J.A. Aguirre, L. de Pablos, F J Alcalde |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Pyridines Piperazines General Biochemistry Genetics and Molecular Biology Rats Sprague-Dawley Immobilization chemistry.chemical_compound History and Philosophy of Science Stress Physiological Corticosterone Internal medicine medicine Animals Acute stress Receptor 8-Hydroxy-2-(di-n-propylamino)tetralin Behavior Animal General Neuroscience Long-term potentiation Serotonin 5-HT1 Receptor Agonists T-maze Rats Serotonin Receptor Agonists Endocrinology chemistry Anxiogenic 5-HT1A receptor Serotonin Antagonists Passive avoidance Psychology |
| Zdroj: | Annals of the New York Academy of Sciences. 1018:333-338 |
| ISSN: | 1749-6632 0077-8923 |
| DOI: | 10.1196/annals.1296.041 |
| Popis: | The long-term behavioral consequences of acute immobilization (IMMO) in rats and the effects of 5-HT(1A) receptor activation (8-OH-DPAT: 0.3 mg/kg, sc) were studied. Corticosterone levels after IMMO with previous 8-OH-DPAT treatment were also studied. Twenty-four hours after IMMO (3 h), rats performed conditioned (passive avoidance) and unconditioned (escape behavior) anxiety tests in the elevated T maze. Pre-exposure to IMMO induces long-term behavioral changes in contrast with control rats. These behavioral alterations include an increase of anxiogenic responses, such as exploratory behavior and passive avoidance response. This effect was counteracted by 8-OH-DPAT pretreatment and reversed by WAY-100635 when administered before 8-OH-DPAT. Serum corticosterone levels increased during the first hour of stress and after 8-OH-DPAT administration. Our results support the hypothesis that involvement of acute stress is crucial in the anxiety-like behaviors and in the potentiation of fear. The activation of 5-HT(1A) receptors counteracted the long-term effects induced by IMMO. |
| Databáze: | OpenAIRE |
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